PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

---

1S9G	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394. 分子名称: 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE, POL polyprotein [Contains: Reverse transcriptase] 著者 Das, K, Clark Jr, A.D, Ludovici, D.W, Kukla, M.J, Decorte, B, Lewi, P.J, Hughes, S.H, Janssen, P.A, Arnold, E. 登録日 2004-02-04 公開日 2004-05-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants. J.Med.Chem., 47, 2004
5T1V	Crystal structure of Zika virus NS2B-NS3 protease in apo-form. 分子名称: NS2B-NS3 protease,NS2B-NS3 protease 著者 Nocadello, S, Light, S.H, Minasov, G, Shuvalova, L, Cardona-Correa, A.A, Ojeda, I, Vargas, J, Johnson, M.E, Lee, H, Anderson, W.F, Center for Structural Genomics of Infectious Diseases, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-08-22 公開日 2016-09-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of Zika virus NS2B-NS3 protease in apo-form. To Be Published
8GUB	Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719 分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. 登録日 2022-09-11 公開日 2022-11-23 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
6GYU	Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-02 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
4AAC	P38ALPHA MAP KINASE BOUND TO CMPD 29 分子名称: CHLORIDE ION, MITOGEN-ACTIVATED PROTEIN KINASE 14, N-isoxazol-3-yl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxo-quinazolin-3-yl]benzamide 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-12-01 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
6G3Y	Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675 分子名称: 4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, ACETATE ION, N-glycosylase/DNA lyase, ... 著者 Masuyer, G, Helleday, T, Stenmark, P. 登録日 2018-03-26 公開日 2018-11-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362, 2018
1RT3	AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91 分子名称: 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE, HIV-1 REVERSE TRANSCRIPTASE 著者 Ren, J, Stammers, D.K, Stuart, D.I. 登録日 1998-06-29 公開日 1999-02-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Proc.Natl.Acad.Sci.USA, 95, 1998
1RTJ	MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS 分子名称: HIV-1 REVERSE TRANSCRIPTASE 著者 Ren, J, Esnouf, R, Ross, C, Jones, Y, Stammers, D, Stuart, D. 登録日 1995-05-03 公開日 1996-04-03 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat.Struct.Biol., 2, 1995
6GYS	Cryo-EM structure of the CBF3-CEN3 complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-01 公開日 2018-12-05 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
6GYP	Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore 分子名称: ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-01 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
3UVN	Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A 分子名称: Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5 著者 Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. 登録日 2011-11-30 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.792 Å) 主引用文献 The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
3UVM	Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 分子名称: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 著者 Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. 登録日 2011-11-30 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
1EBM	CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE 分子名称: 8-OXOGUANINE DNA GLYCOSYLASE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), ... 著者 Bruner, S.D, Norman, D.P, Verdine, G.L. 登録日 2000-01-24 公開日 2000-03-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature, 403, 2000
1SUQ	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545 分子名称: (6-[4-(AMINOMETHYL)-2,6-DIMETHYLPHENOXY]-2-{[4-(AMINOMETHYL)PHENYL]AMINO}-5-BROMOPYRIMIDIN-4-YL)METHANOL, MAGNESIUM ION, REVERSE TRANSCRIPTASE 著者 Das, K, Arnold, E. 登録日 2004-03-26 公開日 2004-05-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants J.Med.Chem., 47, 2004
3UR4	Crystal structure of human WD repeat domain 5 with compound 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... 著者 Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-11-21 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
3UV4	Crystal Structure of the second bromodomain of human Transcription initiation factor TFIID subunit 1 (TAF1) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, PHOSPHATE ION, ... 著者 Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2011-11-29 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149, 2012
7CFQ	Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide 分子名称: 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7CJB	VHL recognizes hydroxyproline in RIPK1 分子名称: Elongin-B, Elongin-C, GLYCEROL, ... 著者 Liu, J, Wang, Y, Pan, L. 登録日 2020-07-09 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 VHL recognizes hydroxyproline in RIPK1 To Be Published
4KIL	7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one bound to influenza 2009 H1N1 endonuclease 分子名称: 1,2-ETHANEDIOL, 7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one, MANGANESE (II) ION, ... 著者 Bauman, J.D, Patel, D, Das, K, Arnold, E. 登録日 2013-05-02 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease. ACS Med Chem Lett, 4, 2013
1SV5	CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335 分子名称: 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, Reverse Transcriptase 著者 Das, K, Arnold, E. 登録日 2004-03-27 公開日 2004-05-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants J.Med.Chem., 47, 2004
4EH3	Human p38 MAP kinase in complex with NP-F2 and RL87 分子名称: Mitogen-activated protein kinase 14, NARINGENIN, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine 著者 Over, B, Gruetter, C, Waldmann, H, Rauh, D. 登録日 2012-04-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5, 2012
4EH6	Human p38 MAP kinase in complex with NP-F5 and RL87 分子名称: Mitogen-activated protein kinase 14, N-phenylpyridine-3-carboxamide, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine 著者 Over, B, Gruetter, C, Waldmann, H, Rauh, D. 登録日 2012-04-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5, 2012
1TQE	Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 分子名称: Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B 著者 Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. 登録日 2004-06-17 公開日 2004-12-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005
6U62	Raptor-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Rogala, K.B, Sabatini, D.M. 登録日 2019-08-29 公開日 2019-10-30 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
4IZ7	Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 分子名称: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, SODIUM ION 著者 Mace, P.D, Robinson, H, Riedl, S.J. 登録日 2013-01-29 公開日 2013-04-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun, 4, 2013

<368369370371372373374375376377378379380381382383>