4KIL
7-(4-fluorophenyl)-3-hydroxyquinolin-2(1H)-one bound to influenza 2009 H1N1 endonuclease
Summary for 4KIL
| Entry DOI | 10.2210/pdb4kil/pdb |
| Descriptor | Polymerase PA, MANGANESE (II) ION, SULFATE ION, ... (6 entities in total) |
| Functional Keywords | endonuclease, cap-snatching, influenza, rna binding protein-inhibitor complex, rna binding protein/inhibitor |
| Biological source | Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1)) |
| Total number of polymer chains | 1 |
| Total formula weight | 25438.52 |
| Authors | Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2013-05-02, release date: 2013-05-29, Last modification date: 2024-02-28) |
| Primary citation | Sagong, H.Y.,Parhi, A.,Bauman, J.D.,Patel, D.,Vijayan, R.S.,Das, K.,Arnold, E.,LaVoie, E.J. 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease. ACS Med Chem Lett, 4:547-550, 2013 Cited by PubMed: 24936242DOI: 10.1021/ml4001112 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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