8J21
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![BU of 8j21 by Molmil](/molmil-images/mine/8j21) | Cryo-EM structure of FFAR3 complex bound with butyrate acid | 分子名称: | Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-01-24 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8JBG
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![BU of 8jbg by Molmil](/molmil-images/mine/8jbg) | Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq (G324), ... | 著者 | Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. | 登録日 | 2023-05-08 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
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8JBH
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![BU of 8jbh by Molmil](/molmil-images/mine/8jbh) | Substance P bound to active human neurokinin 3 receptor in complex with Gq | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq subunit alpha (G324), ... | 著者 | Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. | 登録日 | 2023-05-08 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
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8JBF
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![BU of 8jbf by Molmil](/molmil-images/mine/8jbf) | Senktide bound to active human neurokinin 3 receptor in complex with Gq | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq subunit alpha, ... | 著者 | Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. | 登録日 | 2023-05-08 | 公開日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
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8JT6
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![BU of 8jt6 by Molmil](/molmil-images/mine/8jt6) | 5-HT1A-Gi in complex with compound (R)-IHCH-7179 | 分子名称: | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. | 登録日 | 2023-06-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
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8IY9
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![BU of 8iy9 by Molmil](/molmil-images/mine/8iy9) | Structure of Niacin-GPR109A-G protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IYH
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![BU of 8iyh by Molmil](/molmil-images/mine/8iyh) | Structure of MK6892-GPR109A-G-protein complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IYW
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![BU of 8iyw by Molmil](/molmil-images/mine/8iyw) | Structure of GSK256073-GPR109A-G-protein complex | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-06 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8JHN
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![BU of 8jhn by Molmil](/molmil-images/mine/8jhn) | Structure of MMF-GPR109A-G protein complex | 分子名称: | (E)-4-methoxy-4-oxidanylidene-but-2-enoic acid, G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-05-24 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8JER
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![BU of 8jer by Molmil](/molmil-images/mine/8jer) | Structure of Acipimox-GPR109A-G protein complex | 分子名称: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-05-16 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IZ4
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![BU of 8iz4 by Molmil](/molmil-images/mine/8iz4) | Lysophosphatidylserine receptor GPR34-Gi complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Liu, G, Li, X, Zhang, X. | 登録日 | 2023-04-06 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors To Be Published
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8J6I
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![BU of 8j6i by Molmil](/molmil-images/mine/8j6i) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6L
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![BU of 8j6l by Molmil](/molmil-images/mine/8j6l) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J23
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![BU of 8j23 by Molmil](/molmil-images/mine/8j23) | Cryo-EM structure of FFAR2 complex in apo state | 分子名称: | Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition and activation mechanism of short chain fatty acid receptors FFAR2 and FFAR3 To Be Published
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8JPN
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![BU of 8jpn by Molmil](/molmil-images/mine/8jpn) | Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi | 分子名称: | (2R,3S)-oxirane-2,3-dicarboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, T.X, Tang, W.Q, Li, F.H, Wang, J.Y. | 登録日 | 2023-06-12 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1. Cell Res., 2024
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