8JHN

Structure of MMF-GPR109A-G protein complex

Summary for 8JHN

• Entry DOI: 10.2210/pdb8jhn/pdb
• EMDB information: 36280
• Descriptor: G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hydroxycarboxylic acid receptor 2, ... (6 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 147815.48

Authors

Yadav, M.K.,Sarma, P.,Chami, M.,Banerjee, R.,Shukla, A.K. (deposition date: 2023-05-24, release date: 2024-03-06, Last modification date: 2024-03-20)

• Primary citation: Yadav, M.K.,Sarma, P.,Maharana, J.,Ganguly, M.,Mishra, S.,Zaidi, N.,Dalal, A.,Singh, V.,Saha, S.,Mahajan, G.,Sharma, S.,Chami, M.,Banerjee, R.,Shukla, A.K.; Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.; Nat Commun, 15:1939-1939, 2024; PubMed: 38431681; DOI: 10.1038/s41467-024-46239-2

Experimental method

ELECTRON MICROSCOPY (3.75 Å)