PDB: 2682 件ウェブページステータス検索Chemie searchBIRD

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1Z6P	Glycogen phosphorylase AMP site inhibitor complex 分子名称: 4-{2-[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID, Glycogen phosphorylase, muscle form 著者 Kristiansen, M, Andersen, B, Iversen, L.F, Westergaard, N. 登録日 2005-03-23 公開日 2005-04-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Identification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site J.Med.Chem., 47, 2004
3T3G	Glycogen Phosphorylase b in complex with GlcBrU 分子名称: 5-bromo-1-(beta-D-glucopyranosyl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form 著者 Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. 登録日 2011-07-25 公開日 2012-02-15 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The sigma-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase  b Chemmedchem, 7, 2012
4EL0	Crystal structure of GPb in complex with DK16 分子名称: 3-(beta-D-glucopyranosyl)-6-propylfuro[2,3-d]pyrimidin-2(3H)-one, Glycogen phosphorylase, muscle form 著者 Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. 登録日 2012-04-10 公開日 2012-07-25 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment. Eur.J.Med.Chem., 54, 2012
4KQ5	Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate 分子名称: 1,2-ETHANEDIOL, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Barnett, B.L, Tsoumpra, M.K, Muniz, J.R.C. 登録日 2013-05-14 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate To be Published
3CC2	The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins 分子名称: 23S RIBOSOMAL RNA, 50S ribosomal protein L10E, 50S ribosomal protein L10e, ... 著者 Gurel, G, Blaha, G. 登録日 2008-02-23 公開日 2008-05-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol., 379, 2008
1IRI	Crystal structure of human autocrine motility factor complexed with an inhibitor 分子名称: ERYTHOSE-4-PHOSPHATE, autocrine motility factor 著者 Tanaka, N, Haga, A, Uemura, H, Akiyama, H, Funasaka, T, Nagase, H, Raz, A, Nakamura, K.T. 登録日 2001-10-08 公開日 2002-06-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies. J.Mol.Biol., 318, 2002
1VQ9	The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*CP*CP*AP*(PHE)*(ACA))-3', 50S RIBOSOMAL PROTEIN L10E, ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction. Mol.Cell, 20, 2005
1VQN	The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*CP*CP*(PPU)*(LOF))-3', 5'-R(*CP*CP*AP*(PHE)*(ACA)*(BTN))-3', ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature, 438, 2005
2QN1	Glycogen Phosphorylase b in complex with asiatic acid 分子名称: Glycogen phosphorylase, muscle form, asiatic acid 著者 Zographos, S.E, Leonidas, D.D, Alexacou, K.-M, Hayes, J, Oikonomakos, N.G. 登録日 2007-07-17 公開日 2008-06-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies J.Med.Chem., 51, 2008
4V9F	The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L10E, 50S ribosomal protein L10e, ... 著者 Gabdulkhakov, A. 登録日 2012-11-02 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Revisiting the Haloarcula marismortui 50S ribosomal subunit model. Acta Crystallogr.,Sect.D, 69, 2013
4P0W	Human farnesyl diphosphate synthase in complex with Arenarone and zoledronate 分子名称: 2-{[(1S,2R,4aS,8aR)-1,2,4a-trimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl}cyclohexa-2,5-diene-1,4-dione, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Liu, Y.L, Oldfield, E. 登録日 2014-02-23 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc.Natl.Acad.Sci.USA, 111, 2014
6V0K	Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain 分子名称: GLYCEROL, Terpene synthase 著者 Christianson, D.W, Ronnebaum, T.A. 登録日 2019-11-18 公開日 2020-01-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Higher-order oligomerization of a chimeric alpha beta gamma bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent. J.Struct.Biol., 210, 2020
7Y7E	Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2022-06-22 公開日 2023-10-25 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
3P9W	Crystal structure of an engineered human autonomous VH Domain in complex with VEGF 分子名称: Vascular endothelial growth factor A, human VEGF 著者 Ma, X, Wiesmann, C. 登録日 2010-10-18 公開日 2012-04-18 最終更新日 2013-06-19 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor. J.Mol.Biol., 425, 2013
7S1K	Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Tsai, K, Stojkovic, V, Lee, D.J, Young, I.D, Szal, T, Vazquez-Laslop, N, Mankin, A.S, Fraser, J.S, Galonic Fujimori, D. 登録日 2021-09-02 公開日 2022-01-19 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
1RQI	Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate 分子名称: DIMETHYLALLYL S-THIOLODIPHOSPHATE, DIPHOSPHATE, Geranyltranstransferase, ... 著者 Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J. 登録日 2003-12-05 公開日 2004-03-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Biol.Chem., 279, 2004
2O1O	Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate. 分子名称: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, Putative farnesyl pyrophosphate synthase 著者 Chruszcz, M, Artz, J.D, Dong, A, Dunford, J, Lew, J, Zhao, Y, Kozieradski, I, Kavanaugh, K.L, Oppermann, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Minor, W, Structural Genomics Consortium (SGC) 登録日 2006-11-29 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis Chem.Biol., 15, 2008
8JDL	Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2023-05-14 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
3KRP	Mint heterotetrameric geranyl pyrophosphate synthase in complex with magnesium and GPP 分子名称: 1,2-ETHANEDIOL, GERANYL DIPHOSPHATE, Geranyl diphosphate synthase large subunit, ... 著者 Chang, T.-H, Hsieh, F.-L, Ko, T.-P, Wang, A.H.-J. 登録日 2009-11-19 公開日 2010-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation Plant Cell, 22, 2010
6S0X	Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22) in complex with erythromycin. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Halfon, Y, Matozv, D, Eyal, Z, Bashan, A, Zimmerman, E, Kjeldgaard, J, Ingmer, H, Yonath, A. 登録日 2019-06-18 公開日 2019-08-21 実験手法 ELECTRON MICROSCOPY (2.425 Å) 主引用文献 Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant. Sci Rep, 9, 2019
6S4K	The crystal structure of glycogen phosphorylase in complex with 12 分子名称: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(4-phenyl-1,3-thiazol-2-yl)oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ... 著者 Kyriakis, E, Solovou, T.G.A, Papaioannou, O.S.E, Skamnaki, V.T, Leonidas, D.D. 登録日 2019-06-28 公開日 2020-02-19 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design. Bioorg.Med.Chem., 28, 2020
7UQB	Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... 著者 Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. 登録日 2022-04-19 公開日 2023-03-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.43 Å) 主引用文献 rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
7RYH	A. baumannii Ribosome-TP-6076 complex: Empty 70S 分子名称: (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... 著者 Morgan, C.E, Yu, E.W. 登録日 2021-08-25 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.43 Å) 主引用文献 An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. Mbio, 13, 2022
8IFB	Dibekacin-bound E.coli 70S ribosome in the PURE system 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. 登録日 2023-02-17 公開日 2024-02-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.43 Å) 主引用文献 Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J.Biochem., 175, 2024
7Y7F	Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC) 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2022-06-22 公開日 2023-10-25 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.43 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023

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