6S4K
The crystal structure of glycogen phosphorylase in complex with 12
Summary for 6S4K
Entry DOI | 10.2210/pdb6s4k/pdb |
Descriptor | Glycogen phosphorylase, muscle form, (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(4-phenyl-1,3-thiazol-2-yl)oxane-3,4,5-triol, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
Functional Keywords | phosphorylase, inhibitor, c-beta-d-glucopyranosyl thiazole, transferase |
Biological source | Oryctolagus cuniculus (Rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 97992.90 |
Authors | Kyriakis, E.,Solovou, T.G.A.,Papaioannou, O.S.E.,Skamnaki, V.T.,Leonidas, D.D. (deposition date: 2019-06-28, release date: 2020-02-19) |
Primary citation | Kyriakis, E.,Karra, A.G.,Papaioannou, O.,Solovou, T.,Skamnaki, V.T.,Liggri, P.G.V.,Zographos, S.E.,Szennyes, E.,Bokor, E.,Kun, S.,Psarra, A.G.,Somsak, L.,Leonidas, D.D. The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design. Bioorg.Med.Chem., 28:115196-115196, 2020 Cited by PubMed: 31767404DOI: 10.1016/j.bmc.2019.115196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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