PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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7LUF	HSV1 polymerase ternary complex with dsDNA and PNU-183792 分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ... 著者 Hayes, R.P, Klein, D. 登録日 2021-02-22 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase. Nat Commun, 12, 2021
5E69	Glucocorticoid receptor DNA binding domain - IL8 NF-kB response element complex 分子名称: DNA (5'-D(*AP*TP*CP*GP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*CP*GP*AP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. 登録日 2015-10-09 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
5E6D	Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex 分子名称: DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. 登録日 2015-10-09 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
6L49	H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA 分子名称: DNA (485-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Takizawa, Y, Ho, C.-H, Tachiwana, H, Matsunami, H, Ohi, M, Wolf, M, Kurumizaka, H. 登録日 2019-10-16 公開日 2019-12-04 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (18.9 Å) 主引用文献 Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome. Structure, 28, 2020
6L4A	H3-H3-H3 tri-nucleosome with the 22 base-pair linker DNA 分子名称: DNA (485-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Takizawa, Y, Ho, C.-H, Tachiwana, H, Matsunami, H, Ohi, M, Wolf, M, Kurumizaka, H. 登録日 2019-10-16 公開日 2019-12-04 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (12.3 Å) 主引用文献 Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome. Structure, 28, 2020
4YCX	Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate 分子名称: DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ... 著者 Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. 登録日 2015-02-20 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
3BRF	CSL (Lag-1) bound to DNA with Lin-12 RAM peptide, C2221 分子名称: DNA (5'-D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3'), DNA (5'-D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'), Lin-12 and glp-1 phenotype protein 1, ... 著者 Wilson, J.J, Kovall, R.A. 登録日 2007-12-21 公開日 2008-04-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex. J.Biol.Chem., 283, 2008
5N9G	TFIIIB -TBP/Brf2/DNA and SANT domain of Bdp1- 分子名称: DNA/RNA (25-MER), DNA/RNA (27-MER), SODIUM ION, ... 著者 Gouge, J, Vannini, A, Guthertz, N. 登録日 2017-02-24 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation. Nat Commun, 8, 2017
4IQR	Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA 分子名称: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... 著者 Chandra, V, Huang, P, Kim, Y, Rastinejad, F. 登録日 2013-01-13 公開日 2013-03-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
4GUQ	Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element 分子名称: DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'), Tumor protein p73, ZINC ION 著者 Ethayathulla, A.S, Nguyen, H.T, Viadiu, H. 登録日 2012-08-29 公開日 2013-08-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res., 41, 2013
5WC9	Human Pit-1 and 4xCATT DNA complex 分子名称: DNA (5'-D(*CP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*GP*GP*A)-3'), DNA (5'-D(*CP*CP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*GP*T)-3'), Pituitary-specific positive transcription factor 1 著者 Agarwal, S, Cho, T.Y. 登録日 2017-06-29 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. Nucleic Acids Res., 46, 2018
7AD8	Core TFIIH-XPA-DNA complex with modelled p62 subunit 分子名称: DNA (49-MER), DNA repair protein complementing XP-A cells, General transcription and DNA repair factor IIH helicase subunit XPB, ... 著者 Koelmel, W, Kuper, J, Kisker, C. 登録日 2020-09-14 公開日 2021-07-28 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair. Nucleic Acids Res., 48, 2020
6J50	RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome (tilted conformation) 分子名称: DNA (198-MER), DNA (41-MER), DNA-directed RNA polymerase subunit, ... 著者 Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2019-01-10 公開日 2019-02-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
6J4Z	RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome 分子名称: DNA (198-MER), DNA (42-MER), DNA-directed RNA polymerase subunit, ... 著者 Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2019-01-10 公開日 2019-02-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
6J51	RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome, weak Elf1 (+1 position) 分子名称: DNA (198-MER), DNA (36-MER), DNA-directed RNA polymerase subunit, ... 著者 Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2019-01-10 公開日 2019-02-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
6RO4	Structure of the core TFIIH-XPA-DNA complex 分子名称: DNA repair protein complementing XP-A cells, DNA1, DNA2, ... 著者 Kokic, G, Chernev, A, Tegunov, D, Dienemann, C, Urlaub, H, Cramer, P. 登録日 2019-05-10 公開日 2019-07-03 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of TFIIH activation for nucleotide excision repair. Nat Commun, 10, 2019
6INQ	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA (+1 position) 分子名称: DNA (198-MER), DNA (31-MER), DNA-directed RNA polymerase subunit, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-10-26 公開日 2019-04-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
4HN6	GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex 分子名称: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Youn, C.E, Ortlund, E.A. 登録日 2012-10-18 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.549 Å) 主引用文献 The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
4HN5	GR DNA Binding Domain - TSLP nGRE Complex 分子名称: DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Hudson, W.H, Youn, C.E, Ortlund, E.A. 登録日 2012-10-18 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 The structural basis of direct glucocorticoid-mediated transrepression. Nat.Struct.Mol.Biol., 20, 2013
3NBN	Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA 分子名称: DNA, HES1 promoter, Mastermind-like protein 1, ... 著者 Arnett, K.L, Blacklow, S.C. 登録日 2010-06-03 公開日 2010-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat.Struct.Mol.Biol., 17, 2010
5YI3	Structure of Lactococcus lactis ZitR, C30S mutant in complex with DNA 分子名称: DNA (5'-D(*TP*GP*TP*TP*AP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*A)-3'), ZINC ION, Zinc transport transcriptional regulator 著者 Song, Y, Liu, H, Zhu, R, Yi, C, Chen, P. 登録日 2017-10-01 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA, 114, 2017
7TR7	APE1 product complex with abasic ssDNA 分子名称: DNA (5'-D(P*(3DR)P*CP*GP*AP*TP*GP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION 著者 Freudenthal, B.D, Hoitsma, N.M. 登録日 2022-01-28 公開日 2023-04-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics. Nucleic Acids Res., 51, 2023
1B01	TRANSCRIPTIONAL REPRESSOR COPG/DNA COMPLEX 分子名称: DNA (5'-D(*CP*CP*CP*GP*TP*GP*CP*AP*CP*TP*CP*AP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*GP*AP*TP*TP*GP*CP*AP*TP*TP*GP*AP*GP*TP*GP*CP*AP*CP*GP*G)-3'), TRANSCRIPTIONAL REPRESSOR COPG 著者 Gomis-Rueth, F.X, Sola, M, Acebo, P, Parraga, A, Guasch, A, Eritja, R, Gonzalez, A, Espinosa, M, del Solar, G, Coll, M. 登録日 1999-11-15 公開日 1999-11-19 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator. EMBO J., 17, 1998
6X9K	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A 分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
6X9J	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... 著者 Pathuri, S, Horton, J.R, Cheng, X. 登録日 2020-06-02 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021

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