PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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6FXV	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Gelin, M, Labesse, G. 登録日 2018-03-09 公開日 2019-03-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 None To be published
8VCI	SARS-CoV-2 Frameshift Stimulatory Element with Upstream Multibranch Loop 分子名称: Frameshift Stimulatory Element with Upstream Multi-branch Loop 著者 Peterson, J.M, Becker, S.T, O'Leary, C.A, Juneja, P, Yang, Y, Moss, W.N. 登録日 2023-12-14 公開日 2024-01-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 Structure of the SARS-CoV-2 Frameshift Stimulatory Element with an Upstream Multibranch Loop. Biochemistry, 63, 2024
6G91	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 5-chloranyl-~{N}-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9K	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-2-oxidanyl-1-phenyl-ethyl]ethanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-11 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8IYJ	Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm 分子名称: Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... 著者 Zhou, L.N, Gui, M, Wu, J.P. 登録日 2023-04-05 公開日 2023-07-05 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell, 186, 2023
6G93	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9J	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{R})-1-phenylethyl]ethanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-10 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6FR1	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-15 公開日 2019-03-13 実験手法 X-RAY DIFFRACTION (1.561 Å) 主引用文献 None To be published
8QBM	Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments) 分子名称: MAGNESIUM ION, Retron Ec86 putative ribosyltransferase/DNA-binding protein, Retron Ec86 reverse transcriptase, ... 著者 Carabias del Rey, A, Montoya, G. 登録日 2023-08-24 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
8QBK	Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment) 分子名称: MAGNESIUM ION, Retron Ec86 putative ribosyltransferase/DNA-binding protein, Retron Ec86 reverse transcriptase, ... 著者 Carabias del Rey, A, Montoya, G. 登録日 2023-08-24 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
8QBL	Retron-Eco1 filament with inactive effector (E106A, 2 segments) 分子名称: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retron Ec86 putative ribosyltransferase/DNA-binding protein, ... 著者 Carabias del Rey, A, Montoya, G. 登録日 2023-08-24 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
6FN5	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-02 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.932 Å) 主引用文献 None To be published
6GJD	Erk2 signalling protein 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 1, ... 著者 O'Reilly, M. 登録日 2018-05-16 公開日 2019-01-02 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chem Sci, 9, 2018
6G54	Crystal structure of ERK2 covalently bound to SM1-71 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Mitogen-activated protein kinase 1, ... 著者 Chaikuad, A, Suman, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2018-03-29 公開日 2019-02-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26, 2019
3WYG	Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex 分子名称: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... 著者 Koyama, M, Shirai, N, Matsuura, Y. 登録日 2014-08-26 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
5LAR	Crystal structure of p38 alpha MAPK14 in complex with VPC00628 分子名称: 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 著者 Chaikuad, A, Petersen, L.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2016-06-14 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Novel p38alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library Medchemcomm, 7, 2016
6G9N	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2018-04-11 公開日 2018-05-30 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8AS4	Crystal structure of human beta-arrestin-1 分子名称: Beta-arrestin-1 著者 Jakob, R.P, Panwalkar, V, Grzesiek, S. 登録日 2022-08-18 公開日 2023-06-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Mol.Cell, 83, 2023
2AHM	Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer 分子名称: GLYCEROL, Replicase polyprotein 1ab, heavy chain, ... 著者 Zhai, Y.J, Sun, F, Bartlam, M, Rao, Z. 登録日 2005-07-28 公開日 2005-11-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer NAT.STRUCT.MOL.BIOL., 12, 2005
8ARI	Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament 分子名称: C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinoic acid-induced protein 2 著者 Mullapudi, E, Goradia, N, Wilmanns, M. 登録日 2022-08-16 公開日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament To Be Published
2IC3	Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097 分子名称: (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H (p51 RT), ... 著者 Das, K, Arnold, E. 登録日 2006-09-12 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097. J.Mol.Biol., 365, 2007
3W55	The structure of ERK2 in complex with FR148083 分子名称: (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, Mitogen-activated protein kinase 1 著者 Ohori, M, Kinoshita, T. 登録日 2013-01-21 公開日 2013-02-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Role of a cysteine residue in the active site of ERK and the MAPKK family Biochem.Biophys.Res.Commun., 353, 2007
3DLK	Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A 分子名称: Reverse transcriptase/ribonuclease H, SULFATE ION, p51 RT 著者 Ho, W.C, Bauman, J.D, Himmel, D.M, Das, K, Arnold, E. 登録日 2008-06-27 公開日 2008-10-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res., 36, 2008
1F66	2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z 分子名称: HISTONE H2A.Z, HISTONE H2B, HISTONE H3, ... 著者 Suto, R.K, Clarkson, M.J, Tremethick, D.J, Luger, K. 登録日 2000-06-20 公開日 2000-11-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. Nat.Struct.Biol., 7, 2000
3ZU7	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP kinase ERK2 分子名称: DESIGNED ANKYRIN REPEAT PROTEIN, MITOGEN-ACTIVATED PROTEIN KINASE 1 著者 Kummer, L, Mittl, P.R, Pluckthun, A. 登録日 2011-07-16 公開日 2012-06-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries. Proc.Natl.Acad.Sci.USA, 109, 2012

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