6KNM
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![BU of 6knm by Molmil](/molmil-images/mine/6knm) | Apelin receptor in complex with single domain antibody | 分子名称: | Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION | 著者 | Ma, Y.B, Ding, Y, Song, X, Ma, X, Li, X, Zhang, N, Song, Y, Sun, Y, Shen, Y, Zhong, W, Hu, L.A, Ma, Y.L, Zhang, M.Y. | 登録日 | 2019-08-06 | 公開日 | 2020-01-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure-guided discovery of a single-domain antibody agonist against human apelin receptor. Sci Adv, 6, 2020
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7C4S
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![BU of 7c4s by Molmil](/molmil-images/mine/7c4s) | Sphingosine-1-phosphate receptor 3 with a natural ligand. | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ... | 著者 | Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H. | 登録日 | 2020-05-18 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias. Sci Adv, 7, 2021
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6KPC
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![BU of 6kpc by Molmil](/molmil-images/mine/6kpc) | Crystal structure of an agonist bound GPCR | 分子名称: | 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2,Endolysin | 著者 | Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Wu, M, Liu, Z.J. | 登録日 | 2019-08-15 | 公開日 | 2020-02-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
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7XOU
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![BU of 7xou by Molmil](/molmil-images/mine/7xou) | Structural insights into human brain gut peptide cholecystokinin receptors | 分子名称: | CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | 登録日 | 2022-05-01 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
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6KUY
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![BU of 6kuy by Molmil](/molmil-images/mine/6kuy) | Crystal structure of the alpha2A adrenergic receptor in complex with a partial agonist | 分子名称: | (2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole, Alpha2A adrenergic receptor, DI(HYDROXYETHYL)ETHER | 著者 | Qu, L, Zhou, Q.T, Wu, D, Zhao, S.W. | 登録日 | 2019-09-02 | 公開日 | 2019-12-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of the alpha2A adrenergic receptor in complex with a partial agonist To Be Published
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5XSZ
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![BU of 5xsz by Molmil](/molmil-images/mine/5xsz) | Crystal structure of zebrafish lysophosphatidic acid receptor LPA6 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lysophosphatidic acid receptor 6a,Endolysin,Lysophosphatidic acid receptor 6a | 著者 | Taniguchi, R, Nishizawa, T, Ishitani, R, Nureki, O. | 登録日 | 2017-06-16 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6 Nature, 548, 2017
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6LFL
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![BU of 6lfl by Molmil](/molmil-images/mine/6lfl) | Crystal structure of a class A GPCR | 分子名称: | 4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide, C-X-C chemokine receptor type 2,GlgA glycogen synthase,C-X-C chemokine receptor type 2 | 著者 | Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. | 登録日 | 2019-12-03 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
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8IHK
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![BU of 8ihk by Molmil](/molmil-images/mine/8ihk) | Cryo-EM structure of HCA3-Gi complex with acifran (local) | 分子名称: | (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Soluble cytochrome b562,Hydroxycarboxylic acid receptor 3 | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-02-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
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8IA2
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![BU of 8ia2 by Molmil](/molmil-images/mine/8ia2) | Structure of C5a bound human C5aR1 in complex with Go (Composite map) | 分子名称: | Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | 著者 | Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C. | 登録日 | 2023-02-07 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
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7T8X
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![BU of 7t8x by Molmil](/molmil-images/mine/7t8x) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | 分子名称: | ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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8JXV
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![BU of 8jxv by Molmil](/molmil-images/mine/8jxv) | Clozapine-bound H4R/Gi complex | 分子名称: | 3-chloranyl-6-(4-methylpiperazin-1-yl)-11~{H}-benzo[b][1,4]benzodiazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Y, Xia, R. | 登録日 | 2023-07-01 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
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7VDL
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![BU of 7vdl by Molmil](/molmil-images/mine/7vdl) | |
7VUH
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![BU of 7vuh by Molmil](/molmil-images/mine/7vuh) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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8JLK
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![BU of 8jlk by Molmil](/molmil-images/mine/8jlk) | Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | 登録日 | 2023-06-02 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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7T96
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![BU of 7t96 by Molmil](/molmil-images/mine/7t96) | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-18 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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8HSC
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![BU of 8hsc by Molmil](/molmil-images/mine/8hsc) | Gi bound Orphan GPR20 complex with Fab046 in ligand-free state | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-19 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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5TZY
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![BU of 5tzy by Molmil](/molmil-images/mine/5tzy) | GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3R)-3-cyclopropyl-3-[(2R)-2-(1-{(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl}piperidin-4-yl)-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ... | 著者 | Lu, J, Byrne, N, Patel, S, Sharma, S, Soisson, S.M. | 登録日 | 2016-11-22 | 公開日 | 2017-06-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40. Nat. Struct. Mol. Biol., 24, 2017
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8F7Q
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![BU of 8f7q by Molmil](/molmil-images/mine/8f7q) | Gi bound mu-opioid receptor in complex with beta-endorphin | 分子名称: | Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | 登録日 | 2022-11-20 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structures of the entire human opioid receptor family. Cell, 186, 2023
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7CKW
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![BU of 7ckw by Molmil](/molmil-images/mine/7ckw) | Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Yan, W, Shao, W. | 登録日 | 2020-07-20 | 公開日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
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8J19
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![BU of 8j19 by Molmil](/molmil-images/mine/8j19) | Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex | 分子名称: | 6-nonylpyridine-2,4-diol, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8IJB
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![BU of 8ijb by Molmil](/molmil-images/mine/8ijb) | Cryo-EM structure of human HCAR2-Gi complex with acipimox | 分子名称: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Pan, X, Fang, Y. | 登録日 | 2023-02-27 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8JLP
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![BU of 8jlp by Molmil](/molmil-images/mine/8jlp) | Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex | 分子名称: | 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | 登録日 | 2023-06-02 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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8J1A
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![BU of 8j1a by Molmil](/molmil-images/mine/8j1a) | Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled | 分子名称: | Antibody fragment ScFv16, G-protein coupled receptor 84, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8JLN
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![BU of 8jln by Molmil](/molmil-images/mine/8jln) | T1AM-bound hTAAR1-Gs protein complex | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | 登録日 | 2023-06-02 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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7YAC
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![BU of 7yac by Molmil](/molmil-images/mine/7yac) | Paltusotine-bound SSTR2-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhao, J, Shao, Z. | 登録日 | 2022-06-27 | 公開日 | 2023-04-19 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nat Commun, 14, 2023
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