4GUS
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![BU of 4gus by Molmil](/molmil-images/mine/4gus) | Crystal structure of LSD2-NPAC with H3 in space group P3221 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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5A7R
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![BU of 5a7r by Molmil](/molmil-images/mine/5a7r) | Human poly(ADP-ribose) glycohydrolase in complex with synthetic dimeric ADP-ribose | 分子名称: | BETA-MERCAPTOETHANOL, GLYCEROL, POLY(ADP-RIBOSE) GLYCOHYDROLASE, ... | 著者 | Lambrecht, M.J, Brichacek, M, Barkauskaite, E, Ariza, A, Ahel, I, Hergenrother, P.J. | 登録日 | 2015-07-09 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Synthesis of Dimeric Adp-Ribose and its Structure with Human Poly(Adp-Ribose) Glycohydrolase. J.Am.Chem.Soc., 137, 2015
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4N7V
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![BU of 4n7v by Molmil](/molmil-images/mine/4n7v) | Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment | 分子名称: | Centrosomal protein of 152 kDa, Serine/threonine-protein kinase PLK4 | 著者 | Park, S.-Y, Park, J.-E, Tian, L, Kim, T.-S, Yang, W, Lee, K.S. | 登録日 | 2013-10-16 | 公開日 | 2014-07-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.758 Å) | 主引用文献 | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat.Struct.Mol.Biol., 21, 2014
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4ICX
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![BU of 4icx by Molmil](/molmil-images/mine/4icx) | |
5BNX
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![BU of 5bnx by Molmil](/molmil-images/mine/5bnx) | |
4GUR
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![BU of 4gur by Molmil](/molmil-images/mine/4gur) | Crystal structure of LSD2-NPAC with H3 in space group P21 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. | 登録日 | 2012-08-29 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
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7N4X
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![BU of 7n4x by Molmil](/molmil-images/mine/7n4x) | Structure of human NPC1L1 mutant-W347R | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7N4U
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![BU of 7n4u by Molmil](/molmil-images/mine/7n4u) | Structure of human NPC1L1 | 分子名称: | (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7N4V
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![BU of 7n4v by Molmil](/molmil-images/mine/7n4v) | Structure of cholesterol-bound human NPC1L1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7N6R
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7N6Q
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![BU of 7n6q by Molmil](/molmil-images/mine/7n6q) | Structure of PPPA bound human ACAT2 | 分子名称: | (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3,6-diyl diacetate, CHOLESTEROL, OLEIC ACID, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-08 | 公開日 | 2021-09-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structure of PPPA bound human ACAT2 To Be Published
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7DVE
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![BU of 7dve by Molmil](/molmil-images/mine/7dve) | Crystal structure of FAD-dependent C-glycoside oxidase | 分子名称: | 6'''-hydroxyparomomycin C oxidase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | 著者 | Senda, M, Watanabe, S, Kumano, T, Kobayashi, M, Senda, T. | 登録日 | 2021-01-13 | 公開日 | 2021-09-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | FAD-dependent C -glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7EBM
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![BU of 7ebm by Molmil](/molmil-images/mine/7ebm) | W363A mutant of Chitin-specific solute binding protein from Vibrio harveyi in complex with chitobiose. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Kitaoku, Y, Ubonbal, P, Tran, L.T, Robinson, R.C, Suginta, W. | 登録日 | 2021-03-10 | 公開日 | 2021-09-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. J.Biol.Chem., 297, 2021
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7EBI
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![BU of 7ebi by Molmil](/molmil-images/mine/7ebi) | Chitin-specific solute binding protein from Vibrio harveyi co-crystalized with chitotetraose. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Kitaoku, Y, Ubonbal, P, Tran, L.T, Robinson, R.C, Suginta, W. | 登録日 | 2021-03-09 | 公開日 | 2021-09-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. J.Biol.Chem., 297, 2021
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7N3L
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![BU of 7n3l by Molmil](/molmil-images/mine/7n3l) | Co-complex CYP46A1 with 0420 (compound 6) | 分子名称: | 1,2-ETHANEDIOL, Cholesterol 24-hydroxylase, GLYCEROL, ... | 著者 | Lane, W, Yano, J. | 登録日 | 2021-06-01 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.631 Å) | 主引用文献 | Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J.Med.Chem., 65, 2022
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7N3M
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![BU of 7n3m by Molmil](/molmil-images/mine/7n3m) | Co-complex CYP46A1 with 0431 (compound 17) | 分子名称: | Cholesterol 24-hydroxylase, N,N-dimethyl-1-[4-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl]piperidine-4-carboxamide, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lane, W, Yano, J. | 登録日 | 2021-06-01 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J.Med.Chem., 65, 2022
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7N6F
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![BU of 7n6f by Molmil](/molmil-images/mine/7n6f) | Co-complex CYP46A1 with compound 3f | 分子名称: | (3-fluoroazetidin-1-yl){1-[4-(4-fluorophenyl)pyrimidin-5-yl]piperidin-4-yl}methanone, 1,2-ETHANEDIOL, Cholesterol 24-hydroxylase, ... | 著者 | Lane, W, Gay, S.C. | 登録日 | 2021-06-08 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H) Eur.J.Med.Chem., 240, 2022
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7EBQ
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![BU of 7ebq by Molmil](/molmil-images/mine/7ebq) | The structural analysis of A.Muciniphila sulfatase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Sulfatase | 著者 | Bao, R, Li, C.C, Tang, X.Y, Zhu, Y.B, Song, Y.J, Zhao, N.L, Huang, Q, Mou, X.Y, Luo, G.H, Liu, T.G. | 登録日 | 2021-03-10 | 公開日 | 2022-03-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural analysis of the sulfatase AmAS from Akkermansia muciniphila. Acta Crystallogr D Struct Biol, 77, 2021
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7EBP
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![BU of 7ebp by Molmil](/molmil-images/mine/7ebp) | The structural analysis of A.Muciniphila sulfatase | 分子名称: | CALCIUM ION, GLYCEROL, Sulfatase | 著者 | Bao, R, Li, C.C, Tang, X.Y, Zhu, Y.B, Song, Y.J, Zhao, N.L, Huang, Q, Mou, X.Y, Luo, G.H, Liu, T.G. | 登録日 | 2021-03-10 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.80000055 Å) | 主引用文献 | Structural analysis of the sulfatase AmAS from Akkermansia muciniphila. Acta Crystallogr D Struct Biol, 77, 2021
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7EJK
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![BU of 7ejk by Molmil](/molmil-images/mine/7ejk) | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline | 分子名称: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | 登録日 | 2021-04-02 | 公開日 | 2022-04-13 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJ0
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![BU of 7ej0 by Molmil](/molmil-images/mine/7ej0) | Structure of the alpha2A-adrenergic receptor GoA signaling complex | 分子名称: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | 登録日 | 2021-04-01 | 公開日 | 2022-04-13 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJA
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![BU of 7eja by Molmil](/molmil-images/mine/7eja) | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine | 分子名称: | 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | 登録日 | 2021-04-01 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJ8
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![BU of 7ej8 by Molmil](/molmil-images/mine/7ej8) | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine | 分子名称: | Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Cao, S, Liu, Z, Du, Y. | 登録日 | 2021-04-01 | 公開日 | 2022-04-13 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7DZE
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![BU of 7dze by Molmil](/molmil-images/mine/7dze) | Fabp ground state captured by XFELs | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | 登録日 | 2021-01-25 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem., 14, 2022
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7DZH
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![BU of 7dzh by Molmil](/molmil-images/mine/7dzh) | intermediate of FABP with a delay time of 100 ns | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | 登録日 | 2021-01-25 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem., 14, 2022
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