4N7V

Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment

Summary for 4N7V

• Entry DOI: 10.2210/pdb4n7v/pdb
• Related: 4N7Z
• Descriptor: Serine/threonine-protein kinase PLK4, Centrosomal protein of 152 kDa (3 entities in total)
• Functional Keywords: k/r crater, d-rich motif, centriole biogenesis, cep152, centrosome, cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole: O00444; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O94986
• Total number of polymer chains: 3
• Total formula weight: 60095.92

Authors

Park, S.-Y.,Park, J.-E.,Tian, L.,Kim, T.-S.,Yang, W.,Lee, K.S. (deposition date: 2013-10-16, release date: 2014-07-02, Last modification date: 2023-09-20)

• Primary citation: Park, S.Y.,Park, J.E.,Kim, T.S.,Kim, J.H.,Kwak, M.J.,Ku, B.,Tian, L.,Murugan, R.N.,Ahn, M.,Komiya, S.,Hojo, H.,Kim, N.H.,Kim, B.Y.,Bang, J.K.,Erikson, R.L.,Lee, K.W.,Kim, S.J.,Oh, B.H.,Yang, W.,Lee, K.S.; Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.; Nat.Struct.Mol.Biol., 21:696-703, 2014; PubMed: 24997597; DOI: 10.1038/nsmb.2846

Experimental method

X-RAY DIFFRACTION (2.758 Å)