7N3L

Co-complex CYP46A1 with 0420 (compound 6)

Summary for 7N3L

Entry DOI	10.2210/pdb7n3l/pdb
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	cyp46a1, ch24h, sbdd, drug discovery, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	55588.86
Authors	Lane, W.,Yano, J. (deposition date: 2021-06-01, release date: 2022-02-23, Last modification date: 2023-10-18)
Primary citation	Kajita, Y.,Ikeda, S.,Yoshikawa, M.,Fukuda, H.,Watanabe, E.,Yano, J.,Lane, W.,Miyamoto, M.,Ishii, T.,Nishi, T.,Koike, T. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J.Med.Chem., 65:3343-3358, 2022 Cited by PubMed: 35166541 DOI: 10.1021/acs.jmedchem.1c01898 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.631 Å)

Structure validation