7N3L
Co-complex CYP46A1 with 0420 (compound 6)
Summary for 7N3L
Entry DOI | 10.2210/pdb7n3l/pdb |
Descriptor | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | cyp46a1, ch24h, sbdd, drug discovery, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 55588.86 |
Authors | |
Primary citation | Kajita, Y.,Ikeda, S.,Yoshikawa, M.,Fukuda, H.,Watanabe, E.,Yano, J.,Lane, W.,Miyamoto, M.,Ishii, T.,Nishi, T.,Koike, T. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J.Med.Chem., 65:3343-3358, 2022 Cited by PubMed: 35166541DOI: 10.1021/acs.jmedchem.1c01898 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.631 Å) |
Structure validation
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