PDB: 9786 件ウェブページステータス検索Chemie searchBIRD

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6Y6C	TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Single chain variable, Triggering receptor expressed on myeloid cells 2 著者 Szykowska, A, Preger, C, Williams, E, Mukhopadhyay, S.M.M, McKinley, G, Gruslund, S, Wigren, E, Persson, H, Arrowsmith, C.H, Edwards, A, von Delft, F, Bountra, C, Davis, J.B, Di Daniel, E, Burgess-Brown, N, Bullock, A. 登録日 2020-02-26 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29, 2021
6YMQ	TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Single-chain variable 4, ... 著者 Szykowska, A, Preger, C, Scacioc, A, Mukhopadhyay, S.M.M, McKinley, G, Graslund, S, Wigren, E, Persson, H, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Di Daniel, E, Davis, J.B, Burgess-Brown, N, Bullock, A. 登録日 2020-04-09 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.07 Å) 主引用文献 Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29, 2021
6N78	Structure of the human JAK1 kinase domain with compound 21 分子名称: GLYCEROL, N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 著者 Lupardus, P.J, Brown, D. 登録日 2018-11-27 公開日 2019-04-24 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
6N7A	Structure of the human JAK1 kinase domain with compound 39 分子名称: GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 著者 Lupardus, P.J, Brown, D. 登録日 2018-11-27 公開日 2019-04-24 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
4JR1	Human procaspase-7 bound to Ac-DEVD-CMK 分子名称: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-7 著者 Thomsen, N.D, Wells, J.A. 登録日 2013-03-20 公開日 2013-05-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.149 Å) 主引用文献 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
6XXO	Crystal structure of NB8, a nanobody targeting prostate specific membrane antigen 分子名称: NB_8 著者 Shahar, A, Rosenfeld, L, Papo, N. 登録日 2020-01-28 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer. J.Med.Chem., 63, 2020
6XXP	Crystal structure of NB37, a nanobody targeting prostate specific membrane antigen 分子名称: NB_37 著者 Shahar, A, Rosenfeld, L, Papo, N. 登録日 2020-01-28 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer. J.Med.Chem., 63, 2020
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN 著者 Bier, D, Ottmann, C. 登録日 2013-02-25 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
8DAD	SARS-CoV-2 receptor binding domain in complex with AZ090 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AZ090 Fab Heavy Chain, AZ090 Fab Light Chain, ... 著者 Zong, S, Wang, Z, Gaebler, C, Nussenzweig, M. 登録日 2022-06-13 公開日 2022-08-24 最終更新日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.85 Å) 主引用文献 SARS-CoV-2 receptor binding domain in complex with AZ090 Fab To Be Published
8DI5	Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH F6 著者 Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Subramaniam, S. 登録日 2022-06-28 公開日 2022-08-24 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains. Iscience, 25, 2022
6NAO	Discovery of a high affinity inhibitor of cGAS 分子名称: (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION 著者 Hall, J. 登録日 2018-12-06 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12, 2017
8CZI	Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2 分子名称: Scaffolded Spike protein S2' HR1, Spike protein S2' HR2 著者 Yang, K, Brunger, A.T. 登録日 2022-05-24 公開日 2022-09-07 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.22 Å) 主引用文献 Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc.Natl.Acad.Sci.USA, 119, 2022
6YO6	Structure of iC3b1 分子名称: hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain 著者 Jensen, R.K, Andersen, G.R. 登録日 2020-04-14 公開日 2021-02-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. J Immunol., 206, 2021
4MA7	Crystal structure of mouse prion protein complexed with Promazine 分子名称: Major prion protein, POM1 heavy chain, POM1 light chain, ... 著者 Baral, P.K, Swayampakula, M, James, M.N.G. 登録日 2013-08-15 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural basis of prion inhibition by phenothiazine compounds. Structure, 22, 2014
4JR2	Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK 分子名称: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-7 著者 Thomsen, N.D, Wells, J.A. 登録日 2013-03-20 公開日 2013-05-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4J9R	Human DNA polymerase eta-DNA translocated binary complex with TG mispair 分子名称: DNA (5'-D(*T*AP*CP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*CP*AP*TP*G)-3'), DNA polymerase eta, ... 著者 Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. 登録日 2013-02-16 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta. Proc.Natl.Acad.Sci.USA, 110, 2013
8DIM	CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, CR6261 Fab light chain, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-06-29 公開日 2022-11-16 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.62 Å) 主引用文献 CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab To Be Published
4J9S	Human DNA polymerase eta-DNA translocated binary complex: with TA base pair 分子名称: DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ... 著者 Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. 登録日 2013-02-16 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta. Proc.Natl.Acad.Sci.USA, 110, 2013
6O1C	Alpha-L-fucosidase AlfC D200A mutant in complex with 4-nitrophenyl-a-L-fucopyranoside substrate 分子名称: 4-nitrophenyl 6-deoxy-alpha-L-galactopyranoside, AlfC 著者 Klontz, E.H, Sundberg, E.J. 登録日 2019-02-19 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nat Commun, 11, 2020
8DIU	Cryo-EM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-06-29 公開日 2022-12-14 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 CryoEM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab To be published
8IA8	Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide 分子名称: ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liao, Q, Chen, G, Du, Y, Ye, R.D. 登録日 2023-02-08 公開日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide To Be Published
4L05	Cu/Zn superoxide dismutase from Brucella abortus 分子名称: COPPER (I) ION, COPPER (II) ION, GLYCEROL, ... 著者 Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D. 登録日 2013-05-30 公開日 2013-10-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.098 Å) 主引用文献 Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus. J.Bacteriol., 197, 2015
4M61	Crystal structure of unliganded anti-DNA Fab A52 分子名称: Fab A52 heavy chain, Fab A52 light chain, SULFATE ION 著者 Stanfield, R.L, Eilat, D, Wilson, I.A. 登録日 2013-08-08 公開日 2013-08-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Crystal structure determination of anti-DNA Fab A52. Proteins, 82, 2014
6XUE	Human Ecto-5'-nucleotidase (CD73) in complex with A2396 (compound 74 in publication) in the closed form in crystal form IV 分子名称: 4-[[5-[7-chloranyl-3-(1~{H}-indazol-6-yl)benzotriazol-5-yl]pyrazol-1-yl]methyl]benzenecarbonitrile, 5'-nucleotidase, CALCIUM ION, ... 著者 Strater, N. 登録日 2020-01-19 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J.Med.Chem., 63, 2020
6O1A	Alpha-L-fucosidase AlfC from Lactobacillus casei in complex with alpha-L-fucose product 分子名称: AlfC, beta-L-fucopyranose 著者 Klontz, E.H, Sundberg, E.J. 登録日 2019-02-18 公開日 2020-02-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nat Commun, 11, 2020

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