8CZI

Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2

Summary for 8CZI

Entry DOI	10.2210/pdb8czi/pdb
EMDB information	27098
Descriptor	Scaffolded Spike protein S2' HR1, Spike protein S2' HR2 (2 entities in total)
Functional Keywords	spike, hr1hr2, fusion, scaffold, viral protein
Biological source	Nostoc punctiforme (strain ATCC 29133 / PCC 73102) More
Total number of polymer chains	6
Total formula weight	101083.48
Authors	Yang, K.,Brunger, A.T. (deposition date: 2022-05-24, release date: 2022-09-07, Last modification date: 2023-03-22)
Primary citation	Yang, K.,Wang, C.,Kreutzberger, A.J.B.,Ojha, R.,Kuivanen, S.,Couoh-Cardel, S.,Muratcioglu, S.,Eisen, T.J.,White, K.I.,Held, R.G.,Subramanian, S.,Marcus, K.,Pfuetzner, R.A.,Esquivies, L.,Doyle, C.A.,Kuriyan, J.,Vapalahti, O.,Balistreri, G.,Kirchhausen, T.,Brunger, A.T. Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc.Natl.Acad.Sci.USA, 119:e2210990119-e2210990119, 2022 Cited by PubMed: 36122200 DOI: 10.1073/pnas.2210990119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.22 Å)

Structure validation