8CZI

Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Scaffolded Spike protein S2' HR1	polymer	257	28759.1	3	UniProt (B2J981) UniProt (P0DTC2) Pfam (PF00210) In PDB	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
2	D, E, F	Spike protein S2' HR2	polymer	45	4935.4	3	UniProt (P0DTC2) In PDB	Severe acute respiratory syndrome coronavirus 2

Sequence modifications

A, B, C: 742 - 915 (UniProt: B2J981)

PDB	External Database	Details
Met 732	-	initiating methionine
Ser 733	-	expression tag
His 734	-	expression tag
His 735	-	expression tag
His 736	-	expression tag
His 737	-	expression tag
His 738	-	expression tag
His 739	-	expression tag
Gly 740	-	expression tag
Ser 741	-	expression tag
Ala 916	-	linker

A, B, C: 917 - 988 (UniProt: P0DTC2)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	101083.5
All*	Total formula weight	101083.5

*Water molecules are not included.