4M61

Crystal structure of unliganded anti-DNA Fab A52

Summary for 4M61

Entry DOI	10.2210/pdb4m61/pdb
Descriptor	Fab A52 light chain, Fab A52 heavy chain, SULFATE ION, ... (4 entities in total)
Functional Keywords	immunoglobulin fold, immune system
Biological source	Mus musculus More
Total number of polymer chains	4
Total formula weight	97146.95
Authors	Stanfield, R.L.,Eilat, D.,Wilson, I.A. (deposition date: 2013-08-08, release date: 2013-08-28, Last modification date: 2024-10-30)
Primary citation	Stanfield, R.L.,Eilat, D. Crystal structure determination of anti-DNA Fab A52. Proteins, 82:1674-1678, 2014 Cited by PubMed Abstract: A52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus-like symptoms and has served as a model for that disease for many years. The 1.62 Å crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. PubMed: 24449198 DOI: 10.1002/prot.24514 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation