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7MB3
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM145
分子名称: 3C-like proteinase, N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM145
To Be Published
7MAT
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFR
分子名称: 3C-like proteinase, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-phenylalaninamide, SULFATE ION
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFR
To Be Published
7MB2
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM144
分子名称: 3C-like proteinase, 4-fluoro-N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM144
To Be Published
7MB1
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM143
分子名称: 3C-like proteinase, 4-fluoro-D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM143
To Be Published
7MAW
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129
分子名称: 3C-like proteinase, ethyl (4R)-4-({3-cyclopropyl-N-[(2E)-3-(4-ethynylphenyl)prop-2-enoyl]-L-alanyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM129
To Be Published
7MAV
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFCit-yne
分子名称: 3C-like proteinase, N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-[(3S)-6-(carbamoylamino)-2-oxohexan-3-yl]-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFCit-yne
To Be Published
7MAX
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM137
分子名称: 3C-like proteinase, D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-4-fluoro-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM137
To Be Published
7MAU
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFR-yne
分子名称: 1,4-DIETHYLENE DIOXIDE, 3C-like proteinase, N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-[(3S)-6-carbamimidamido-2-oxohexan-3-yl]-L-phenylalaninamide, ...
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor dFFR-yne
To Be Published
7MB0
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SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM141
分子名称: 3C-like proteinase, D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide
著者Lockbaum, G.J, Schiffer, C.A.
登録日2021-03-31
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM141
To Be Published
7NFV
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Structure of SARS-CoV-2 Papain-like protease PLpro
分子名称: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
著者Srinivasan, V, Gunther, S, Reinke, P, Werner, N, Falke, S, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Sprenger, J, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Koua, F, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Ewert, W, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Ehrt, C, Rarey, M, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Hinrichs, W, Meents, A, Betzel, C.
登録日2021-02-07
公開日2021-02-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022
7NIO
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Crystal structure of the SARS-CoV-2 helicase APO form
分子名称: SARS-CoV-2 helicase NSP13, ZINC ION
著者Newman, J.A, Yosaatmadja, Y, Douangamath, A, Bountra, C, Gileadi, O.
登録日2021-02-12
公開日2021-03-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Nat Commun, 12, 2021
7NN0
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Crystal structure of the SARS-CoV-2 helicase in complex with AMP-PNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SARS-CoV-2 helicase NSP13, ...
著者Newman, J.A, Yosaatmadja, Y, Douangamath, A, Bountra, C, Gileadi, O.
登録日2021-02-23
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Nat Commun, 12, 2021
7NG3
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Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 in spacegroup P1.
分子名称: 3C-like proteinase, CHLORIDE ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
著者Costanzi, E, Demitri, N, Giabbai, B, Storici, P.
登録日2021-02-08
公開日2021-04-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L.
Int J Mol Sci, 22, 2021
7NG6
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Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 in spacegroup P1 in absence of DTT.
分子名称: 3C-like proteinase, ACETATE ION, CHLORIDE ION, ...
著者Costanzi, E, Demitri, N, Giabbai, B, Storici, P.
登録日2021-02-08
公開日2021-04-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L.
Int J Mol Sci, 22, 2021
8OWT
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SARS-CoV-2 spike RBD with A8 and H3 nanobodies bound
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody A8, ...
著者Mikolajek, H, Naismith, J.H, Owens, R.J.
登録日2023-04-28
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8OWW
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B5-5 nanobody bound to SARS-CoV-2 spike RBD (Wuhan)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, B5-5 nanobody, ...
著者Cornish, K.A.S, Naismith, J.H, Owens, R.J.
登録日2023-04-28
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.969 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8OWV
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H6 and F2 nanobodies bound to SARS-CoV-2 spike RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F2, GLYCEROL, ...
著者Mikolajek, H, Naismith, J.H, Owens, R.J.
登録日2023-04-28
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8OYU
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Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '2 up 1 down' RBD conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
著者Weckener, M, Naismith, J.H, Owens, R.J.
登録日2023-05-05
公開日2024-05-15
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8OYT
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Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
著者Weckener, M, Naismith, J.H, Owens, R.J.
登録日2023-05-05
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024
8Q93
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Crystal structure of the SARS-COV-2 RBD with neutralizing-VHHs Re30H02 and Re21D01
分子名称: Nanobody Re21D01, Nanobody Re30H02, Spike protein S1
著者Aksu, M, Guttler, T, Rymarenko, O, Gorlich, D.
登録日2023-08-19
公開日2023-12-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Antiviral Res., 221, 2023
8Q95
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Crystal structure of the SARS-CoV-2 BA.1 RBD with neutralizing-VHHs Ma16B06 and Ma3F05
分子名称: Nanobody Ma16B06, Nanobody Ma3F05, Spike protein S1
著者Aksu, M, Rymarenko, O, Guttler, T, Gorlich, D.
登録日2023-08-19
公開日2023-12-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Antiviral Res., 221, 2023
8Q94
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Crystal structure of The SARS-COV-2 BA.2.75 RBD with neutralizing-VHHs Re32D03 and Ma3B12
分子名称: Nanobody Ma3B12, Nanobody Re32D03, Spike protein S1
著者Aksu, M, Guttler, T, Gorlich, D.
登録日2023-08-19
公開日2023-12-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Antiviral Res., 221, 2023
8Q7S
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Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01
分子名称: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, GLYCEROL, ...
著者Guttler, T, Aksu, M, Gorlich, D.
登録日2023-08-16
公開日2023-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Antiviral Res., 221, 2023
8Q4O
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RNA G-quadruplex from the 5'-UTR of human tyrosine kinase 2 (TYK2)
分子名称: RNA (5'-R(*CP*GP*GP*UP*AP*GP*CP*GP*GP*GP*UP*AP*UP*GP*GP*GP*UP*CP*CP*GP*GP*GP*U)-3')
著者Toplishek, M, Kocman, V.
登録日2023-08-07
公開日2024-03-06
実験手法SOLUTION NMR
主引用文献High-Resolution Structure of RNA G-Quadruplex Containing Unique Structural Motifs Originating from the 5'-UTR of Human Tyrosine Kinase 2 (TYK2).
Acs Omega, 9, 2024
8QPR
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SARS-CoV-2 S protein bound to human neutralising antibody UZGENT_G5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IgG heavy chain - FAB, ...
著者Remaut, H, Reiter, D, Vandenkerckhove, L, Acar, D.D, Witkowski, W, Gerlo, S.
登録日2023-10-03
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted.
Ebiomedicine, 100, 2024

224004

件を2024-08-21に公開中

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