8Q7S

Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01

Summary for 8Q7S

Entry DOI	10.2210/pdb8q7s/pdb
Descriptor	Spike protein S1, VHH Antibody Re21H01, VHH Antibody Ma6F06, ... (7 entities in total)
Functional Keywords	sars-cov-2, vhh antibody, nanobody, antiviral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	15
Total formula weight	242450.91
Authors	Guttler, T.,Aksu, M.,Gorlich, D. (deposition date: 2023-08-16, release date: 2023-12-20, Last modification date: 2024-01-17)
Primary citation	Aksu, M.,Kumar, P.,Guttler, T.,Taxer, W.,Gregor, K.,Mussil, B.,Rymarenko, O.,Stegmann, K.M.,Dickmanns, A.,Gerber, S.,Reineking, W.,Schulz, C.,Henneck, T.,Mohamed, A.,Pohlmann, G.,Ramazanoglu, M.,Mese, K.,Gross, U.,Ben-Yedidia, T.,Ovadia, O.,Fischer, D.W.,Kamensky, M.,Reichman, A.,Baumgartner, W.,von Kockritz-Blickwede, M.,Dobbelstein, M.,Gorlich, D. Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Res., 221:105778-105778, 2023 Cited by PubMed: 38065245 DOI: 10.1016/j.antiviral.2023.105778 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation