8Q7S
Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J, M (A, D, G, J, M) | Spike protein S1 | polymer | 196 | 21949.5 | 5 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 | |
| 2 | B, E, H, K, N (B, E, H, K, N) | VHH Antibody Re21H01 | polymer | 117 | 12350.7 | 5 | Vicugna pacos | ||
| 3 | C, F, I, L, O (C, F, I, L, O) | VHH Antibody Ma6F06 | polymer | 131 | 14052.6 | 5 | Vicugna pacos | ||
| 4 | P (A) | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | non-polymer | 162.2 | 1 | Chemie (P4G) | |||
| 5 | Q, R, S, W (B, F, O) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | T, U, V (G, M) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | AA, BA, CA, DA, EA... (D, E, F, G, H...) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, D, G, J, M: 334 - 526 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 331 | - | expression tag |
| Gly 332 | - | expression tag |
| Ser 333 | - | expression tag |
| Asp 343 | Asn 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 241764.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 686.8 | |
| All* | Total formula weight | 242450.9 |
