8Q93

Crystal structure of the SARS-COV-2 RBD with neutralizing-VHHs Re30H02 and Re21D01

Summary for 8Q93

Entry DOI	10.2210/pdb8q93/pdb
Descriptor	Spike protein S1, Nanobody Re21D01, Nanobody Re30H02 (3 entities in total)
Functional Keywords	neutralizing vhh, fold-promoter, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	3
Total formula weight	48617.90
Authors	Aksu, M.,Guttler, T.,Rymarenko, O.,Gorlich, D. (deposition date: 2023-08-19, release date: 2023-12-20, Last modification date: 2023-12-27)
Primary citation	Aksu, M.,Kumar, P.,Guttler, T.,Taxer, W.,Gregor, K.,Mussil, B.,Rymarenko, O.,Stegmann, K.M.,Dickmanns, A.,Gerber, S.,Reineking, W.,Schulz, C.,Henneck, T.,Mohamed, A.,Pohlmann, G.,Ramazanoglu, M.,Mese, K.,Gross, U.,Ben-Yedidia, T.,Ovadia, O.,Fischer, D.W.,Kamensky, M.,Reichman, A.,Baumgartner, W.,von Kockritz-Blickwede, M.,Dobbelstein, M.,Gorlich, D. Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Res., 221:105778-105778, 2023 Cited by PubMed: 38065245 DOI: 10.1016/j.antiviral.2023.105778 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation