5DAD
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![BU of 5dad by Molmil](/molmil-images/mine/5dad) | Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64014 | 分子名称: | (6aS,7S,10aS)-8-hydroxy-4-methoxy-2,7,10a-trimethyl-5,6,6a,7,10,10a-hexahydrobenzo[h]quinazoline-9-carbonitrile, Kelch-like ECH-associated protein 1 | 著者 | Huerta, C, Jiang, X, Trevino, I, Bender, C.F, Swinger, K.K, Stoll, V.S, Ferguson, D.A, Thomas, P.J, Probst, B, Dulubova, I, Visnick, M, Wigley, W.C. | 登録日 | 2015-08-19 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding. Biochim.Biophys.Acta, 1860, 2016
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8RS9
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![BU of 8rs9 by Molmil](/molmil-images/mine/8rs9) | p97 (VCP) double mutant - F266A F539A | 分子名称: | Transitional endoplasmic reticulum ATPase | 著者 | Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. | 登録日 | 2024-01-24 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | p97 (VCP) double mutant - F266A F539A To Be Published
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8R74
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![BU of 8r74 by Molmil](/molmil-images/mine/8r74) | Galectin-1 in complex with thiogalactoside derivative | 分子名称: | (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(2-oxidanyl-1,3-thiazol-4-yl)-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-1 | 著者 | Hakansson, M, Diehl, C, Peterson, K, Zetterberg, F, Nilsson, U. | 登録日 | 2023-11-23 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. J.Med.Chem., 67, 2024
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2FZ3
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8RG1
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![BU of 8rg1 by Molmil](/molmil-images/mine/8rg1) | Soluble glucose dehydrogenase from acinetobacter calcoaceticus - wild type pH8 | 分子名称: | 3-(3,5-dicarboxy-1~{H}-pyrrol-2-yl)pyridine-2,4,6-tricarboxylic acid, CALCIUM ION, LITHIUM ION, ... | 著者 | Lublin, V, Chavas, L, Stines-Chaumeil, C, Kauffmann, B, Giraud, M.F, Thompson, A. | 登録日 | 2023-12-13 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Does Acinetobacter calcoaceticus glucose dehydrogenase produce self-damaging H2O2? Biosci.Rep., 44, 2024
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5DAS
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![BU of 5das by Molmil](/molmil-images/mine/5das) | |
2FWP
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5DB2
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![BU of 5db2 by Molmil](/molmil-images/mine/5db2) | Menin in complex with MI-389 | 分子名称: | 2-{2-cyano-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indol-1-yl}aceta mide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-20 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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2FZD
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![BU of 2fzd by Molmil](/molmil-images/mine/2fzd) | Human aldose reductase complexed with tolrestat at 1.08 A resolution. | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, aldose reductase | 著者 | Steuber, H, Zentgraf, M, Gerlach, C, Sotriffer, C.A, Heine, A, Klebe, G. | 登録日 | 2006-02-09 | 公開日 | 2006-10-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions. J.Mol.Biol., 363, 2006
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8REF
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![BU of 8ref by Molmil](/molmil-images/mine/8ref) | Crystal structure of HLA B*13:01 in complex with SVLNDILARL, an 10-mer epitope from SARS-CoV-2 Spike (S975-984) | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ahn, Y.M, Maddumage, J.C, Szeto, C, Gras, S. | 登録日 | 2023-12-11 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Curr Res Struct Biol, 7, 2024
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8RH6
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![BU of 8rh6 by Molmil](/molmil-images/mine/8rh6) | Crystal structure of HLA-A*11:01 in complex with SVLNDILSRL, an 10-mer epitope from SARS-CoV-2 Spike (S975-984) | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ahn, Y.M, Maddumage, J.C, Szeto, C, Gras, S. | 登録日 | 2023-12-15 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Curr Res Struct Biol, 7, 2024
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2G0G
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![BU of 2g0g by Molmil](/molmil-images/mine/2g0g) | Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities | 分子名称: | 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE, Peroxisome proliferator-activated receptor gamma | 著者 | Lu, I.L, Peng, Y.H, Huang, C.F, Lin, Y.T, Hsu, J.T.A, Wu, S.Y. | 登録日 | 2006-02-13 | 公開日 | 2006-05-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities J.Med.Chem., 49, 2006
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5DBS
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8RVK
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![BU of 8rvk by Molmil](/molmil-images/mine/8rvk) | Maltodextrin phosphorylase (MalP) in complex with a alpha-1,2-cyclophellitol analogue | 分子名称: | (3~{a}~{R},4~{R},5~{R},6~{R},7~{a}~{S})-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-1,3-benzoxazol-2-one, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Bennett, M, Ofman, T.P, Overkleeft, H.S, Davies, G.J. | 登録日 | 2024-02-01 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining alpha-Glucosidase Inhibition. Chemistry, 30, 2024
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8S86
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![BU of 8s86 by Molmil](/molmil-images/mine/8s86) | human PLD3 homodimer structure | 分子名称: | 5'-3' exonuclease PLD3 | 著者 | Lammens, K. | 登録日 | 2024-03-05 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation. Immunity, 2024
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2FXV
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![BU of 2fxv by Molmil](/molmil-images/mine/2fxv) | Bacillus subtilis Xanthine Phosphoribosyltransferase in Complex with Guanosine 5'-monophosphate (GMP) | 分子名称: | GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, Xanthine phosphoribosyltransferase | 著者 | Arent, S, Kadziola, A, Larsen, S, Neuhard, J, Jensen, K.F. | 登録日 | 2006-02-06 | 公開日 | 2006-06-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The Extraordinary Specificity of Xanthine Phosphoribosyltransferase from Bacillus subtilis Elucidated
by Reaction Kinetics, Ligand Binding, and Crystallography Biochemistry, 45, 2006
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8R9S
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![BU of 8r9s by Molmil](/molmil-images/mine/8r9s) | A soakable crystal form of human CDK7 in complex with AMP-PNP | 分子名称: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, Cyclin-dependent kinase 7, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mukherjee, M, Cleasby, A. | 登録日 | 2023-11-30 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024
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2G0Y
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![BU of 2g0y by Molmil](/molmil-images/mine/2g0y) | Crystal Structure of a Lumenal Pentapeptide Repeat Protein from Cyanothece sp 51142 at 2.3 Angstrom Resolution. Tetragonal Crystal Form | 分子名称: | CALCIUM ION, pentapeptide repeat protein | 著者 | Kennedy, M.A, Ni, S, Buchko, G.W, Robinson, H. | 登録日 | 2006-02-13 | 公開日 | 2006-11-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterization of two potentially universal turn motifs that shape the repeated five-residues fold - Crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142 Protein Sci., 15, 2006
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8S4S
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![BU of 8s4s by Molmil](/molmil-images/mine/8s4s) | PrgE from plasmid pCF10 | 分子名称: | POTASSIUM ION, PrgE, SULFATE ION | 著者 | Breidenstein, A, Berntsson, R.P.-A. | 登録日 | 2024-02-22 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs. Life Sci Alliance, 7, 2024
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5DCH
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![BU of 5dch by Molmil](/molmil-images/mine/5dch) | Crystal structure of Pseudomonas aeruginosa DsbA E82I in complex with MIPS-0000851 (3-[(2-METHYLBENZYL)SULFANYL]-4H-1,2,4-TRIAZOL-4-AMINE) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine, GLYCEROL, ... | 著者 | McMahon, R.M, Martin, J.L. | 登録日 | 2015-08-24 | 公開日 | 2016-10-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.447 Å) | 主引用文献 | Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1. PLoS ONE, 12, 2017
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8SNO
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![BU of 8sno by Molmil](/molmil-images/mine/8sno) | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 | 分子名称: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 | 著者 | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | 登録日 | 2023-04-27 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 To Be Published
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2FYY
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8ROZ
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5DDE
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![BU of 5dde by Molmil](/molmil-images/mine/5dde) | Menin in complex with MI-859 | 分子名称: | 1,2-ETHANEDIOL, 6-(2,2-difluoroethyl)-4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ... | 著者 | Pollock, J, Dmitry, B, Cierpicki, T, Grembecka, J. | 登録日 | 2015-08-24 | 公開日 | 2015-09-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J.Med.Chem., 58, 2015
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8RBU
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![BU of 8rbu by Molmil](/molmil-images/mine/8rbu) | Crystal structure of HLA-A*11:01 in complex with SVLNDILARL, an 10-mer epitope from SARS-CoV-2 Spike (S975-984) | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Ahn, Y.M, Maddumage, J.C, Szeto, C, Gras, S. | 登録日 | 2023-12-05 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific. Curr Res Struct Biol, 7, 2024
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