2FZD
Human aldose reductase complexed with tolrestat at 1.08 A resolution.
Summary for 2FZD
| Entry DOI | 10.2210/pdb2fzd/pdb |
| Related | 1ah3 2FZ9 2fz8 2fzb |
| Descriptor | aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total) |
| Functional Keywords | tim-barrel, high resolution crystal structure, protein-ligand complex, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 36999.09 |
| Authors | Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. (deposition date: 2006-02-09, release date: 2006-10-03, Last modification date: 2023-08-30) |
| Primary citation | Steuber, H.,Zentgraf, M.,Gerlach, C.,Sotriffer, C.A.,Heine, A.,Klebe, G. Expect the Unexpected or Caveat for Drug Designers: Multiple Structure Determinations Using Aldose Reductase Crystals Treated under Varying Soaking and Co-crystallisation Conditions. J.Mol.Biol., 363:174-187, 2006 Cited by PubMed: 16952371DOI: 10.1016/j.jmb.2006.08.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.08 Å) |
Structure validation
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