7XM8
 
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7XM7
 | | Crystal Structure of the CBP in complex with the Y08188 | | 分子名称: | 1,2-ETHANEDIOL, 3-ethanoyl-~{N}-[2-fluoranyl-3-(1-methylpyrazol-4-yl)phenyl]-7-methoxy-indolizine-1-carboxamide, CREB-binding protein, ... | | 著者 | Xiang, Q, Zhang, Y, Wang, C, Song, M, Xu, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors
To Be Published
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7XM5
 | | Keap1 Kelch domain (residues 322-609) in complex with 6i | | 分子名称: | Kelch-like ECH-associated protein 1, N-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]-3-morpholin-4-yl-propanamide | | 著者 | Xu, K. | | 登録日 | 2022-04-24 | | 公開日 | 2022-07-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.
J.Med.Chem., 65, 2022
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7XM3
 | | Crystal structure of Keap1 Kelch domain (residues 322-609) in complex with 6k | | 分子名称: | Kelch-like ECH-associated protein 1, N-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]-3-(4-ethylpiperazin-1-yl)propanamide | | 著者 | Xu, K. | | 登録日 | 2022-04-24 | | 公開日 | 2022-07-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.
J.Med.Chem., 65, 2022
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7XM1
 | | Cryo-EM structure of mTIP60-Ba (metal-ion induced TIP60 (K67E) complex with barium ions | | 分子名称: | BARIUM ION, TIP60 K67E mutant | | 著者 | Ohara, N, Kawakami, N, Arai, R, Adachi, N, Moriya, T, Kawasaki, M, Miyamoto, K. | | 登録日 | 2022-04-24 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Reversible Assembly of an Artificial Protein Nanocage Using Alkaline Earth Metal Ions.
J.Am.Chem.Soc., 145, 2023
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7XLI
 | | Crystal structure of IsdB linker-NEAT2 bound to a nanobody (VHH) | | 分子名称: | CALCIUM ION, CHLORIDE ION, Iron-regulated surface determinant protein B, ... | | 著者 | Caaveiro, J.M.M, Valenciano-Bellido, S, Tsumoto, K. | | 登録日 | 2022-04-21 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth.
J.Biol.Chem., 299, 2023
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7XLF
 | | Crystal structure of CH3-THF complex of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6 | | 分子名称: | 5,10-methylenetetrahydrofolate reductase, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Yu, H.Y, Senda, M, Senda, T. | | 登録日 | 2022-04-21 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structural of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6
To Be Published
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7XLD
 | | Crystal structure of IsdH linker-NEAT3 bound to a nanobody (VHH) | | 分子名称: | Iron-regulated surface determinant protein H, MAGNESIUM ION, Nanobody VHH6, ... | | 著者 | Caaveiro, J.M.M, Valenciano-Bellido, S, Tsumoto, K. | | 登録日 | 2022-04-21 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth.
J.Biol.Chem., 299, 2023
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7XLB
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7XL7
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7XL6
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7XL5
 | | Crystal structure of the H42T/A85G/I86A mutant of a nadp-dependent alcohol dehydrogenase | | 分子名称: | NADP-dependent isopropanol dehydrogenase | | 著者 | Jiang, Y.Y, Qu, G, Li, X, Sun, Z.T, Han, X, Liu, W.D. | | 登録日 | 2022-04-21 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (2.604 Å) | | 主引用文献 | Engineering the hydrogen transfer pathway of an alcohol dehydrogenase to increase activity by rational enzyme design
Mol Catal, 530, 2022
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7XL1
 | | Crystal structure of chimeric 7D12-Vob nanobody at 1.65 Angstrom | | 分子名称: | Chimeric 7D12-Vob nanobody, MALONATE ION | | 著者 | Caaveiro, J.M.M, Kinoshita, S, Mori, C, Nakakido, M, Tsumoto, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3.
Protein Sci., 31, 2022
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7XL0
 | | Crystal structure of Vobarilizumab at 1.70 Angstrom | | 分子名称: | GLYCEROL, Nanobody Vobarilizumab, SULFATE ION | | 著者 | Caaveiro, J.M.M, Mori, C, Kinoshita, S, Nakakido, M, Tsumoto, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3.
Protein Sci., 31, 2022
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7XKS
 | | Crystal structure of an alkaline pectate lyase from Bacillus clausii | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Pectate lyase | | 著者 | Zhou, C, Zheng, Y.Y, Liu, W.D, Ma, Y. | | 登録日 | 2022-04-20 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structure of an Alkaline Pectate Lyase and Rational Engineering with Improved Thermo-Alkaline Stability for Efficient Ramie Degumming.
Int J Mol Sci, 24, 2022
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7XKR
 | | F1 domain of FoF1-ATPase with the up form of epsilon subunit from Bacillus PS3 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | 著者 | Nakano, A, Kishikawa, J, Nakanishi, A, Mitsuoka, K, Yokoyama, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural basis of unisite catalysis of bacterial F 0 F 1 -ATPase.
Pnas Nexus, 1, 2022
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7XKQ
 | | F1 domain of FoF1-ATPase with the down form of epsilon subunit from Bacillus PS3 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | 著者 | Nakano, A, Kishikawa, J, Nakanishi, A, Mitsuoka, K, Yokoyama, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of unisite catalysis of bacterial F 0 F 1 -ATPase.
Pnas Nexus, 1, 2022
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7XKP
 | | F1 domain of epsilon C-terminal domain deleted FoF1 from Bacillus PS3,state1,unisite condition | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP synthase gamma chain, ATP synthase subunit alpha, ... | | 著者 | Nakano, A, Kishikawa, J, Nakanishi, A, Mitsuoka, K, Yokoyama, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of unisite catalysis of bacterial F 0 F 1 -ATPase.
Pnas Nexus, 1, 2022
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7XKO
 | | F1 domain of epsilon C-terminal domain deleted FoF1 from Bacillus PS3,state1,nucleotide depeleted | | 分子名称: | ATP synthase gamma chain, ATP synthase subunit alpha, ATP synthase subunit beta, ... | | 著者 | Nakano, A, Kishikawa, J, Nakanishi, A, Mitsuoka, K, Yokoyama, K. | | 登録日 | 2022-04-20 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of unisite catalysis of bacterial F 0 F 1 -ATPase.
Pnas Nexus, 1, 2022
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7XKM
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7XKH
 | | Nucleotide-depleted F1 domain of FoF1-ATPase from Bacillus PS3, state1 | | 分子名称: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit alpha, ... | | 著者 | Nakano, A, Kishikawa, J, Nakanishi, A, Mitsuoka, K, Yokoyama, K. | | 登録日 | 2022-04-19 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of unisite catalysis of bacterial F 0 F 1 -ATPase.
Pnas Nexus, 1, 2022
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7XK9
 | | Structure of human beta2 adrenergic receptor bound to constrained isoproterenol | | 分子名称: | (5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ... | | 著者 | Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P. | | 登録日 | 2022-04-19 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.
Nat Commun, 14, 2023
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7XK7
 | | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with korormicin | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | | 登録日 | 2022-04-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae.
Nat Commun, 13, 2022
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7XK6
 | | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, with aurachin D-42 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Aurachin D, CALCIUM ION, ... | | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | | 登録日 | 2022-04-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae.
Nat Commun, 13, 2022
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7XK5
 | | Cryo-EM structure of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae, state 3 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Kishikawa, J, Ishikawa, M, Masuya, T, Murai, M, Barquera, B, Miyoshi, H. | | 登録日 | 2022-04-19 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures of Na + -pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae.
Nat Commun, 13, 2022
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