7XL0

Crystal structure of Vobarilizumab at 1.70 Angstrom

Summary for 7XL0

Entry DOI	10.2210/pdb7xl0/pdb
Descriptor	Nanobody Vobarilizumab, SULFATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	nanobody vhh protein engineering protein stability surface plasmon resonance differential scanning calorimetry, immune system
Biological source	Lama glama
Total number of polymer chains	2
Total formula weight	28445.64
Authors	Caaveiro, J.M.M.,Mori, C.,Kinoshita, S.,Nakakido, M.,Tsumoto, K. (deposition date: 2022-04-20, release date: 2022-11-09, Last modification date: 2023-11-29)
Primary citation	Kinoshita, S.,Nakakido, M.,Mori, C.,Kuroda, D.,Caaveiro, J.M.M.,Tsumoto, K. Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3. Protein Sci., 31:e4450-e4450, 2022 Cited by PubMed: 36153698 DOI: 10.1002/pro.4450 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation