PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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1L8Y	Solution structure of HMG box 5 in human upstream binding factor 分子名称: upstream binding factor 1 著者 Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. 登録日 2002-03-22 公開日 2002-06-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
1K6C	LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 分子名称: ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, POL polyprotein 著者 Schiffer, C.A. 登録日 2001-10-15 公開日 2002-02-06 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein Sci., 11, 2002
2XW9	Crystal Structure of Complement Factor D mutant S183A 分子名称: COMPLEMENT FACTOR D, GLYCEROL 著者 Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. 登録日 2010-11-01 公開日 2011-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
1K6P	LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE 分子名称: ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, POL polyprotein 著者 Schiffer, C.A. 登録日 2001-10-16 公開日 2002-02-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein Sci., 11, 2002
3HUD	THE STRUCTURE OF HUMAN BETA 1 BETA 1 ALCOHOL DEHYDROGENASE: CATALYTIC EFFECTS OF NON-ACTIVE-SITE SUBSTITUTIONS 分子名称: ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION 著者 Hurley, T.D, Bosron, W.F, Hamilton, J.A, Amzel, L.M. 登録日 1993-01-04 公開日 1994-01-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Proc.Natl.Acad.Sci.USA, 88, 1991
2X4S	Crystal structure of MHC CLass I HLA-A2.1 bound to a peptide representing the epitope of the H5N1 (Avian Flu) Nucleoprotein 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ... 著者 Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M. 登録日 2010-02-02 公開日 2010-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals J.Am.Chem.Soc., 131, 2009
5SZK	Structure of human N-terminally engineered Rab1b in complex with the bMERB domain of Mical-cL 分子名称: MAGNESIUM ION, MICAL C-terminal-like protein, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Gazdag, E.M, Mueller, M.P. 登録日 2016-08-14 公開日 2016-08-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife, 5, 2016
5UFG	Crystal Structure of CYP2B6 (Y226H/K262R/I114V) in complex with myrtenyl bromide 分子名称: (1S,5R)-2-(bromomethyl)-6,6-dimethylbicyclo[3.1.1]hept-2-ene, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B6, ... 著者 Shah, M.B, Halpert, J.R. 登録日 2017-01-04 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Halogen-pi Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity. ACS Chem. Biol., 12, 2017
3L9M	Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18 分子名称: (2S)-N~1~-[5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Huang, X. 登録日 2010-01-05 公開日 2011-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20, 2010
2X4O	Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 envelope peptide env120-128 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, ENVELOPE GLYCOPROTEIN GP160, ... 著者 Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M. 登録日 2010-02-02 公開日 2010-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Uv-Induced Ligand Exchange in Mhc Class I Protein Crystals. J.Am.Chem.Soc., 131, 2009
3LM1	Crystal Structure Analysis of Maclura pomifera agglutinin complex with p-nitrophenyl-GalNAc 分子名称: 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, Agglutinin alpha chain, Agglutinin beta-2 chain 著者 Huang, J, Xu, Z, Wang, D, Ogato, C, Hirama, T, Palczewski, K, Hazen, S.L, Lee, X, Young, N.M. 登録日 2010-01-29 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology, 20, 2010
2XOY	C-terminal cysteine-rich domain of human CHFR bound to P(1),P(2)- Diadenosine-5'-pyrophosphate 分子名称: ADENINE, ADENOSINE MONOPHOSPHATE, E3 UBIQUITIN-PROTEIN LIGASE CHFR, ... 著者 Oberoi, J, Bayliss, R. 登録日 2010-08-24 公開日 2010-09-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Basis of Poly(Adp-Ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-Associated and Ring Domains (Chfr). J.Biol.Chem., 285, 2010
1LG4	NMR structure of the human doppel protein fragment 24-152 分子名称: Prion-like protein 著者 Luhrs, T, Riek, R, Guntert, P, Wuthrich, K. 登録日 2002-04-15 公開日 2003-02-25 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 NMR Structure of the Human Doppel Protein J.Mol.Biol., 326, 2003
2XOZ	C-terminal cysteine rich domain of human CHFR bound to AMP 分子名称: ADENOSINE MONOPHOSPHATE, E3 UBIQUITIN-PROTEIN LIGASE CHFR, ZINC ION 著者 Oberoi, J, Bayliss, R. 登録日 2010-08-24 公開日 2010-09-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.374 Å) 主引用文献 Structural Basis of Poly(Adp-Ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-Associated and Ring Domains (Chfr). J.Biol.Chem., 285, 2010
3I3T	Crystal structure of covalent ubiquitin-USP21 complex 分子名称: ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ... 著者 Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2009-06-30 公開日 2009-07-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
3I7P	Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR40A 分子名称: DNA damage-binding protein 1, WD repeat-containing protein 40A 著者 Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. 登録日 2009-07-08 公開日 2009-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
4FDU	Crystal Structure of a Multiple Inositol Polyphosphate Phosphatase 分子名称: 1,2-ETHANEDIOL, D-MYO-INOSITOL-HEXASULPHATE, Putative multiple inositol polyphosphate histidine phosphatase 1 著者 Li, A.W.H, Hemmings, A.M. 登録日 2012-05-29 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.293 Å) 主引用文献 A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Rep, 6, 2014
5VNG	Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal II sorting motif 分子名称: C-terminal ILE-ILE, Protein transport protein Sec23A, Protein transport protein Sec24A, ... 著者 Ma, W, Goldberg, J. 登録日 2017-04-30 公開日 2017-07-05 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate. Elife, 6, 2017
3HMO	Crystal structure of human Mps1 catalytic domain in complex with the inhibitor staurosporine 分子名称: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK, GLYCEROL, ... 著者 Chu, M.L.H, Chavas, L.M.G, Williams, D.H, Tabernero, L, Eyers, P.A. 登録日 2009-05-29 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. Biochemistry, 49, 2010
1JIQ	Crystal Structure of Human Autocrine Motility Factor 分子名称: autocrine motility factor 著者 Tanaka, N, Haga, A, Uemura, H, Akiyama, H, Funasaka, T, Nagase, H, Raz, A, Nakamura, K.T. 登録日 2001-07-02 公開日 2002-06-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies. J.Mol.Biol., 318, 2002
3HR0	Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4 分子名称: CoG4 著者 Richardson, B.C, Ungar, D, Nakamura, A, Jeffrey, P.D, Hughson, F.M. 登録日 2009-06-08 公開日 2009-07-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc.Natl.Acad.Sci.USA, 106, 2009
2VUW	Structure of human haspin kinase domain 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ... 著者 Eswaran, J, Murray, J.W, Filippakopoulos, P, Soundararajan, M, Pike, A.C.W, von Delft, F, Picaud, S, Keates, T, King, O, Wickstroem, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Fedorov, O, Burgess-Brown, N, Bray, J, Knapp, S. 登録日 2008-05-30 公開日 2008-09-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and Functional Characterization of the Atypical Human Kinase Haspin. Proc.Natl.Acad.Sci.USA, 106, 2009
5P9G	Structure of BTK with RN486 分子名称: 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one, Tyrosine-protein kinase BTK 著者 Gardberg, A.S. 登録日 2016-09-20 公開日 2017-05-24 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91, 2017
5P9M	BTK1 BINDS COVALENTLY TO HY-15771 ONO-4059 分子名称: 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK 著者 Gardberg, A.S. 登録日 2016-09-20 公開日 2017-05-24 最終更新日 2021-11-17 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91, 2017
3L5K	The crystal structure of human Haloacid Dehalogenase-like Hydrolase Domain containing 1A (HDHD1A) 分子名称: CHLORIDE ION, GLYCEROL, Haloacid dehalogenase-like hydrolase domain-containing protein 1A, ... 著者 Ugochukwu, E, Guo, K, Picaud, S, Muniz, J, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Yue, W.W, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2009-12-22 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of human Haloacid Dehalogenase-like Hydrolase Domain containing 1A (HDHD1A) To be Published

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