3L9M

Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18

Summary for 3L9M

Entry DOI	10.2210/pdb3l9m/pdb
Related	3L9L 3L9N
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2S)-N~1~-[5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine, ... (4 entities in total)
Functional Keywords	pkb, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm (By similarity): P17612
Total number of polymer chains	4
Total formula weight	86809.02
Authors	Huang, X. (deposition date: 2010-01-05, release date: 2011-01-19, Last modification date: 2023-09-06)
Primary citation	Zeng, Q.,Allen, J.G.,Bourbeau, M.P.,Wang, X.,Yao, G.,Tadesse, S.,Rider, J.T.,Yuan, C.C.,Hong, F.T.,Lee, M.R.,Zhang, S.,Lofgren, J.A.,Freeman, D.J.,Yang, S.,Li, C.,Tominey, E.,Huang, X.,Hoffman, D.,Yamane, H.K.,Fotsch, C.,Dominguez, C.,Hungate, R.,Zhang, X. Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg.Med.Chem.Lett., 20:1559-1564, 2010 Cited by PubMed: 20137943 DOI: 10.1016/j.bmcl.2010.01.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation