1QAD
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![BU of 1qad by Molmil](/molmil-images/mine/1qad) | Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate | 分子名称: | PI3-KINASE P85 ALPHA SUBUNIT | 著者 | Hoedemaeker, P.J, Siegal, G, Roe, M, Driscoll, P.C, Abrahams, J.P.A. | 登録日 | 1999-02-26 | 公開日 | 1999-10-27 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate. J.Mol.Biol., 292, 1999
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3PH2
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3KSQ
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![BU of 3ksq by Molmil](/molmil-images/mine/3ksq) | Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors | 分子名称: | FARNESYL DIPHOSPHATE, Farnesyltransferase, CAAX box, ... | 著者 | Zhu, H.Y, Cooper, A.B, Njoroge, G, Kirschmeier, P, Strickland, C, Hruza, A, Girijavallabhan, V.M. | 登録日 | 2009-11-23 | 公開日 | 2010-01-26 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3BUX
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![BU of 3bux by Molmil](/molmil-images/mine/3bux) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | 分子名称: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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1ZH1
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4OAZ
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![BU of 4oaz by Molmil](/molmil-images/mine/4oaz) | BldD CTD-c-di-GMP complex | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative DNA-binding protein | 著者 | Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G. | 登録日 | 2014-01-06 | 公開日 | 2014-11-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
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1ZUB
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![BU of 1zub by Molmil](/molmil-images/mine/1zub) | Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide | 分子名称: | ELKS1b, Regulating synaptic membrane exocytosis protein 1 | 著者 | Lu, J, Li, H, Wang, Y, Sudhof, T.C, Rizo, J. | 登録日 | 2005-05-30 | 公開日 | 2005-08-30 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide J.Mol.Biol., 352, 2005
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3EA2
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![BU of 3ea2 by Molmil](/molmil-images/mine/3ea2) | Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ZINC ION | 著者 | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | 登録日 | 2008-08-24 | 公開日 | 2009-04-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface. J.Biol.Chem., 284, 2009
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2OC8
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![BU of 2oc8 by Molmil](/molmil-images/mine/2oc8) | Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034 | 分子名称: | BETA-MERCAPTOETHANOL, Hepatitis C virus, ZINC ION, ... | 著者 | Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R.S, Arasappan, A, Bennett, F, Bogen, S.L, Chen, K, Jao, E, Liu, Y.T, Lovey, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V. | 登録日 | 2006-12-20 | 公開日 | 2007-07-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J.Med.Chem., 50, 2007
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7VU7
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2YOJ
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![BU of 2yoj by Molmil](/molmil-images/mine/2yoj) | HCV NS5B polymerase complexed with pyridonylindole compound | 分子名称: | 4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid, PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Chen, K.X, Venkatraman, S, Anilkumar, G.N, Zeng, Q, Lesburg, C.A, Vibulbhan, B, Yang, W, Velazquez, F, Chan, T.-Y, Bennett, F, Sannigrahi, M, Jiang, Y, Duca, J.S, Pinto, P, Gavalas, S, Huang, Y, Wu, W, Selyutin, O, Agrawal, S, Feld, B, Huang, H.-C, Li, C, Cheng, K.-C, Shih, N.-Y, Kozlowski, J.A, Rosenblum, S.B, Njoroge, F.G. | 登録日 | 2012-10-24 | 公開日 | 2013-10-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Discovery of Sch 900188: A Potent Hepatitis C Virus Ns5B Polymerase Inhibitor Prodrug as a Development Candidate Acs Med.Chem.Lett., 5, 2014
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3BUW
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![BU of 3buw by Molmil](/molmil-images/mine/3buw) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | 分子名称: | 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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1XX0
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![BU of 1xx0 by Molmil](/molmil-images/mine/1xx0) | Structure of the C-terminal PH domain of human pleckstrin | 分子名称: | Pleckstrin | 著者 | Edlich, C, Stier, G, Simon, B, Sattler, M, Muhle-Goll, C. | 登録日 | 2004-11-03 | 公開日 | 2005-05-03 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin STRUCTURE, 13, 2005
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1KIB
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![BU of 1kib by Molmil](/molmil-images/mine/1kib) | cytochrome c6 from Arthrospira maxima: an assembly of 24 subunits in the form of an oblate shell | 分子名称: | HEME C, cytochrome c6 | 著者 | Kerfeld, C.A, Sawaya, M.R, Krogmann, D, Yeates, T.O. | 登録日 | 2001-12-03 | 公開日 | 2002-07-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of cytochrome c6 from Arthrospira maxima: an assembly of 24 subunits in a nearly symmetric shell. Acta Crystallogr.,Sect.D, 58, 2002
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1T45
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![BU of 1t45 by Molmil](/molmil-images/mine/1t45) | STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE | 分子名称: | Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 著者 | Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P. | 登録日 | 2004-04-28 | 公開日 | 2004-06-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279, 2004
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3BUO
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![BU of 3buo by Molmil](/molmil-images/mine/3buo) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' | 分子名称: | 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3EA3
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![BU of 3ea3 by Molmil](/molmil-images/mine/3ea3) | Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | 分子名称: | 1-phosphatidylinositol phosphodiesterase, MANGANESE (II) ION | 著者 | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | 登録日 | 2008-08-24 | 公開日 | 2009-04-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Modulation of Bacillus thuringiensis Phosphatidylinositol-specific Phospholipase C Activity by Mutations in the Putative Dimerization Interface. J.Biol.Chem., 284, 2009
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3BUN
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![BU of 3bun by Molmil](/molmil-images/mine/3bun) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | 分子名称: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | 登録日 | 2008-01-03 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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4OR2
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![BU of 4or2 by Molmil](/molmil-images/mine/4or2) | Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide, CHOLESTEROL, ... | 著者 | Wu, H, Wang, C, Gregory, K.J, Han, G.W, Cho, H.P, Xia, Y, Niswender, C.M, Katritch, V, Cherezov, V, Conn, P.J, Stevens, R.C, GPCR Network (GPCR) | 登録日 | 2014-02-10 | 公開日 | 2014-03-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Science, 344, 2014
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1AH7
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![BU of 1ah7 by Molmil](/molmil-images/mine/1ah7) | PHOSPHOLIPASE C FROM BACILLUS CEREUS | 分子名称: | PHOSPHOLIPASE C, ZINC ION | 著者 | Greaves, R. | 登録日 | 1997-04-14 | 公開日 | 1997-12-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature, 338, 1989
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4MIA
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![BU of 4mia by Molmil](/molmil-images/mine/4mia) | Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with RG7109 (N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide) | 分子名称: | N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide, RNA-directed RNA polymerase, ZINC ION | 著者 | Harris, S.F, Villasenor, A.G. | 登録日 | 2013-08-30 | 公開日 | 2014-05-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. J.Med.Chem., 57, 2014
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5ZZ2
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![BU of 5zz2 by Molmil](/molmil-images/mine/5zz2) | Crystal structure of PDE5 in complex with inhibitor LW1634 | 分子名称: | 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ... | 著者 | Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B. | 登録日 | 2018-05-29 | 公開日 | 2018-09-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem., 61, 2018
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1Z5Y
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![BU of 1z5y by Molmil](/molmil-images/mine/1z5y) | Crystal Structure Of The Disulfide-Linked Complex Between The N-Terminal Domain Of The Electron Transfer Catalyst DsbD and The Cytochrome c Biogenesis Protein CcmG | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Thiol:disulfide interchange protein dsbD, ... | 著者 | Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Gruetter, M.G, Glockshuber, R, Capitani, G. | 登録日 | 2005-03-21 | 公開日 | 2005-07-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural Basis and Kinetics of DsbD-Dependent Cytochrome c Maturation STRUCTURE, 13, 2005
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2LEV
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![BU of 2lev by Molmil](/molmil-images/mine/2lev) | Structure of the DNA complex of the C-Terminal domain of Ler | 分子名称: | DNA (5'-D(*CP*CP*TP*AP*TP*CP*AP*AP*TP*TP*AP*TP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*AP*TP*AP*AP*TP*TP*GP*AP*TP*AP*GP*G)-3'), Ler | 著者 | Cordeiro, T.N, Schimdt, H, Madrid, C, Juarez, A, Bernado, P, Grisienger, C, Garcia, J, Pons, M. | 登録日 | 2011-06-23 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | Indirect DNA Readout by an H-NS Related Protein: Structure of the DNA Complex of the C-Terminal Domain of Ler. Plos Pathog., 7, 2011
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4OJJ
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![BU of 4ojj by Molmil](/molmil-images/mine/4ojj) | Structure of C-terminal domain from S. cerevisiae Pat1 decapping activator (Space group : P212121) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA topoisomerase 2-associated protein PAT1, ... | 著者 | Fourati-Kammoun, Z, Kolesnikova, O, Back, R, Keller, J, Lazar, N, Gaudon-Plesse, C, Seraphin, B, Graille, M. | 登録日 | 2014-01-21 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | The C-terminal domain from S. cerevisiae Pat1 displays two conserved regions involved in decapping factor recruitment. Plos One, 9, 2014
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