4HEE
Crystal structure of PPARgamma in complex with compound 13
Summary for 4HEE
Entry DOI | 10.2210/pdb4hee/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 5-benzyl-2-ethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one, ... (4 entities in total) |
Functional Keywords | ppargamma, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 35649.30 |
Authors | |
Primary citation | Casimiro-Garcia, A.,Heemstra, R.J.,Bigge, C.F.,Chen, J.,Ciske, F.A.,Davis, J.A.,Ellis, T.,Esmaeil, N.,Flynn, D.,Han, S.,Jalaie, M.,Ohren, J.F.,Powell, N.A. Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-gamma Bioorg.Med.Chem.Lett., 23:767-772, 2013 Cited by PubMed: 23265881DOI: 10.1016/j.bmcl.2012.11.088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report