4HEE
Crystal structure of PPARgamma in complex with compound 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Peroxisome proliferator-activated receptor gamma | polymer | 282 | 32329.5 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (Y) | Nuclear receptor coactivator 1 | polymer | 25 | 2806.2 | 1 | UniProt (Q15788) Pfam (PF08832) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | C (X) | 5-benzyl-2-ethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one | non-polymer | 513.6 | 1 | Chemie (14R) | |||
| 4 | D, E (X, Y) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
X: 207 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 196 | - | expression tag |
| Lys 197 | - | expression tag |
| Lys 198 | - | expression tag |
| Gly 199 | - | expression tag |
| His 200 | - | expression tag |
| His 201 | - | expression tag |
| His 202 | - | expression tag |
| His 203 | - | expression tag |
| His 204 | - | expression tag |
| His 205 | - | expression tag |
| Gly 206 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35135.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 513.6 | |
| All* | Total formula weight | 35649.3 |
