5WFI
 
 | |
5W8U
 | | Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ORF1ab, Ubiquitin-like protein ISG15, ... | | 著者 | Daczkowski, C.M, Goodwin, O.Y, Dzimianski, J.D, Pegan, S.D. | | 登録日 | 2017-06-22 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.411 Å) | | 主引用文献 | Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.
J. Virol., 91, 2017
|
|
5WQ4
 | |
5YMY
 | | The structure of the complex between Rpn13 and K48-diUb | | 分子名称: | Proteasomal ubiquitin receptor ADRM1, Ubiquitin | | 著者 | Liu, Z, Dong, X, Gong, Z, Yi, H.W, Liu, K, Yang, J, Zhang, W.P, Tang, C. | | 登録日 | 2017-10-22 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13.
Cell Discov, 5, 2019
|
|
5YIJ
 | | Structure of a Legionella effector with substrates | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SdeA, Ubiquitin | | 著者 | Feng, Y, Mu, Y, Wang, H. | | 登録日 | 2017-10-05 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Structural basis of ubiquitin modification by the Legionella effector SdeA.
Nature, 557, 2018
|
|
5VZM
 | |
5XVE
 | |
5XU8
 | |
5ZQ4
 | | PDE-Ubi-ADPr | | 分子名称: | ADENOSINE MONOPHOSPHATE, SidE, ubiquitin | | 著者 | Wang, Y, Gao, A, Gao, P. | | 登録日 | 2018-04-17 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.217 Å) | | 主引用文献 | Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE.
Cell, 173, 2018
|
|
5ZQ3
 | | PDE-Ubiquitin | | 分子名称: | SidE, Ubiquitin | | 著者 | Wang, Y, Gao, A, Gao, P. | | 登録日 | 2018-04-17 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.182 Å) | | 主引用文献 | Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE.
Cell, 173, 2018
|
|
6GFZ
 | | pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b) | | 分子名称: | (2~{R},3~{S},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | 著者 | Gadd, M.S, Testa, A, Ciulli, A. | | 登録日 | 2018-05-02 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.
J. Am. Chem. Soc., 140, 2018
|
|
6GFY
 | | pVHL:EloB:EloC in complex with modified VH032 containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 14a) | | 分子名称: | (2~{R},3~{R},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | 著者 | Gadd, M.S, Testa, A, Ciulli, A. | | 登録日 | 2018-05-02 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.
J. Am. Chem. Soc., 140, 2018
|
|
6GMQ
 | | pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol | | 分子名称: | (4-pyrrol-1-ylphenyl)methanol, ACETATE ION, Elongin-B, ... | | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | | 登録日 | 2018-05-28 | | 公開日 | 2018-08-22 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
|
|
6GMN
 | | pVHL:EloB:EloC in complex with methyl 4H-furo[3,2-b]pyrrole-5-carboxylate | | 分子名称: | ACETATE ION, Elongin-B, Elongin-C, ... | | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | | 登録日 | 2018-05-27 | | 公開日 | 2018-08-08 | | 最終更新日 | 2018-09-05 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
|
|
6H4H
 | | Usp28 catalytic domain variant E593D in complex with UbPA | | 分子名称: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28, ... | | 著者 | Klemm, T.A, Sauer, F, Kisker, C. | | 登録日 | 2018-07-21 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Mol.Cell, 74, 2019
|
|
6HR2
 | | Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB | | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | | 著者 | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | | 登録日 | 2018-09-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
|
|
6HEK
 | |
6HAX
 | | Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Roy, M, Bader, G, Diers, E, Trainor, N, Farnaby, W, Ciulli, A. | | 登録日 | 2018-08-09 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Nat.Chem.Biol., 15, 2019
|
|
6HUE
 | | ParkinS65N | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | | 著者 | McWilliams, T.G, Barini, E, Pohjolan-Pirhonen, R, Brooks, S.P, Singh, F, Burel, S, Balk, K, Kumar, A, Montava-Garriga, L, Prescott, A.R, Hassoun, S.M, Mouton-Liger, F, Ball, G, Hills, R, Knebel, A, Ulusoy, A, Di Monte, D.A, Tamjar, J, Antico, O, Fears, K, Smith, L, Brambilla, R, Palin, E, Valori, M, Eerola-Rautio, J, Tienari, P, Corti, O, Dunnett, S.B, Ganley, I.G, Suomalainen, A, Muqit, M.M.K. | | 登録日 | 2018-10-07 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Phosphorylation of Parkin at serine 65 is essential for its activation in vivo .
Open Biology, 8, 2018
|
|
6HIW
 | | Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the complete small mitoribosomal subunit in complex with mt-IF-3 | | 分子名称: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Ramrath, D, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2018-08-31 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362, 2018
|
|
6HEI
 | |
6I7R
 | |
6I7Q
 | |
6GZS
 | |
6GMR
 | | pVHL:EloB:EloC in complex with (4-(1H-pyrrol-1-yl)phenyl)methanol | | 分子名称: | (4-pyrrol-1-ylphenyl)methanol, Elongin-B, Elongin-C, ... | | 著者 | Van Molle, I, Lucas, X, Ciulli, A. | | 登録日 | 2018-05-28 | | 公開日 | 2018-08-08 | | 最終更新日 | 2018-09-05 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
J. Med. Chem., 61, 2018
|
|
