5XU8
Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine
Summary for 5XU8
Entry DOI | 10.2210/pdb5xu8/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, 2-amino-1,9-dihydro-6H-purine-6-thione, ... (7 entities in total) |
Functional Keywords | ternary complex, esi complex, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm . Isoform 4: Nucleus : O75604 Ubiquitin: Cytoplasm : P62992 |
Total number of polymer chains | 2 |
Total formula weight | 50311.30 |
Authors | Chou, C.Y.,Chuang, S.J. (deposition date: 2017-06-22, release date: 2018-02-28, Last modification date: 2023-11-22) |
Primary citation | Chuang, S.J.,Cheng, S.C.,Tang, H.C.,Sun, C.Y.,Chou, C.Y. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8:3102-3102, 2018 Cited by PubMed: 29449607DOI: 10.1038/s41598-018-21476-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
Download full validation report