5XU8

Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ubiquitin carboxyl-terminal hydrolase 2	polymer	356	41209.7	1	UniProt (O75604) Pfam (PF00443) In PDB	Homo sapiens (Human)	41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquitin thioesterase 2,Ubiquitin-specific-processing protease 2
2	B	Ubiquitin-40S ribosomal protein S27a	polymer	76	8576.8	1	UniProt (P62992) Pfam (PF00240) In PDB	Bos taurus (Bovine)	Ubiquitin carboxyl extension protein 80
3	A	2-amino-1,9-dihydro-6H-purine-6-thione	non-polymer		167.2	1	Chemie (DX4)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A, B	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
6	A	SODIUM ION	non-polymer		23.0	5	Chemie (NA)
7		water	water		18.0	261	Chemie (HOH)

Sequence modifications

A: 258 - 605 (UniProt: O75604)

PDB	External Database	Details
Leu 606	-	expression tag
Glu 607	-	expression tag
His 608	-	expression tag
His 609	-	expression tag
His 610	-	expression tag
His 611	-	expression tag
His 612	-	expression tag
His 613	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49786.5
Non-Polymers*	Number of molecules	12
	Total formula weight	524.8
All*	Total formula weight	50311.3

*Water molecules are not included.