Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue DX4 A 701 |
| Chain | Residue |
| A | LEU269 |
| A | ASP575 |
| A | SER576 |
| A | CYS276 |
| A | ASN279 |
| A | SER280 |
| A | GLN283 |
| A | TYR558 |
| A | THR559 |
| A | ALA560 |
| A | PHE573 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 702 |
| Chain | Residue |
| A | CYS425 |
| A | CYS428 |
| A | CYS476 |
| A | CYS479 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 703 |
| Chain | Residue |
| A | SER513 |
| A | LYS514 |
| A | THR552 |
| A | THR553 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 704 |
| Chain | Residue |
| A | SER308 |
| A | TRP400 |
| A | ARG493 |
| A | HOH891 |
| A | HOH906 |
| A | HOH947 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 705 |
| Chain | Residue |
| A | SER506 |
| A | GLU507 |
| A | SER508 |
| A | THR512 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 706 |
| Chain | Residue |
| A | TYR403 |
| A | HOH991 |
| B | ALA46 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 707 |
| Chain | Residue |
| A | SER421 |
| A | LYS487 |
| A | NA708 |
| B | GLU64 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 708 |
| Chain | Residue |
| A | SER421 |
| A | LEU423 |
| A | SER432 |
| A | NA707 |
| B | GLU64 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 709 |
| Chain | Residue |
| A | SER308 |
| A | ASN309 |
| A | ASP408 |
| A | SER409 |
| A | ASP413 |
| A | HOH940 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 101 |
| Chain | Residue |
| A | HOH850 |
| B | LYS27 |
| B | GLN41 |
| B | GLN49 |
| B | HOH212 |
| B | HOH222 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 102 |
| Chain | Residue |
| A | GLU507 |
| B | THR7 |
| B | LEU8 |
| B | THR9 |
| B | GLY10 |
| B | LYS11 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 103 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 | |
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLrnlGNtCFMNSiLQ |
| Chain | Residue | Details |
| A | GLY268-GLN283 | |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLyAVsnHsGttmg..GHY |
| Chain | Residue | Details |
| A | TYR541-TYR558 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Region: {"description":"Necessary for interaction with MDM4","evidences":[{"source":"PubMed","id":"19838211","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16905103","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interacts with activating enzyme"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for function"} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"P62979","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylglycine","evidences":[{"source":"UniProtKB","id":"P62979","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 7 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P62979","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)"} |
