5W8U

Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15

Summary for 5W8U

Entry DOI	10.2210/pdb5w8u/pdb
Descriptor	ORF1ab, Ubiquitin-like protein ISG15, ZINC ION, ... (6 entities in total)
Functional Keywords	signaling protein, hydrolase, papain-like protease, isg15
Biological source	Human betacoronavirus 2c EMC/2012 More
Total number of polymer chains	4
Total formula weight	90826.84
Authors	Daczkowski, C.M.,Goodwin, O.Y.,Dzimianski, J.D.,Pegan, S.D. (deposition date: 2017-06-22, release date: 2017-09-27, Last modification date: 2024-04-24)
Primary citation	Daczkowski, C.M.,Goodwin, O.Y.,Dzimianski, J.V.,Farhat, J.J.,Pegan, S.D. Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus. J. Virol., 91:-, 2017 Cited by PubMed: 28931677 DOI: 10.1128/JVI.01067-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.411 Å)

Structure validation