PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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5GNM	Cytochrome P450 Vdh (CYP107BR1) L348M mutant 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Vitamin D(3) 25-hydroxylase 著者 Yasutake, Y, Tamura, T. 登録日 2016-07-22 公開日 2017-05-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3 hydroxylase (CYP107BR1) caused by a mutation distant from the active site Acta Crystallogr F Struct Biol Commun, 73, 2017
5GNL	Cytochrome P450 Vdh (CYP107BR1) F106V mutant 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, PROTOPORPHYRIN IX CONTAINING FE, Vitamin D(3) 25-hydroxylase 著者 Yasutake, Y, Tamura, T. 登録日 2016-07-22 公開日 2017-05-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3 hydroxylase (CYP107BR1) caused by a mutation distant from the active site Acta Crystallogr F Struct Biol Commun, 73, 2017
5UCW	Cytochrome P411 P-4 A82L A78V F263L amination catalyst 分子名称: NADPH-cytochrome P450 reductase 102A1V3, PROTOPORPHYRIN IX CONTAINING FE 著者 Zhang, R.K, Buller, A.R, Arnold, F.H. 登録日 2016-12-22 公開日 2017-05-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme. Nat Chem, 9, 2017
5VC0	Crystal structure of human CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-30 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VCE	Crystal structure of the cysteine depleted CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VCC	Crystal structure of human CYP3A4 bound to glycerol 分子名称: 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VBU	Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex 分子名称: (9beta)-17-hydroxypregn-4-ene-3,20-dione, Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Pallan, P.S, Egli, M. 登録日 2017-03-30 公開日 2017-05-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia. J. Biol. Chem., 292, 2017
5VCD	Crystal structure of the cysteine depleted CYP3A4 bound to glycerol 分子名称: Cytochrome P450 3A4, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VCG	Crystal structure of the cysteine depleted CYP3A4 bound to bromoergocryptine 分子名称: Cytochrome P450 3A4, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5G5J	Crystal structure of human CYP3A4 bound to metformin 分子名称: CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I. 登録日 2016-05-25 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24, 2017
5K7K	Design and Optimization of Biaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7: Discovery of Clinical Candidate PF-05089771 分子名称: 4-[4-chloranyl-2-(1~{H}-pyrazol-4-yl)phenoxy]-3-cyano-~{N}-(1,3-thiazol-2-yl)benzenesulfonamide, Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE 著者 Swain, N, Chrencik, J. 登録日 2016-05-26 公開日 2017-06-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7. J. Med. Chem., 60, 2017
5VWS	Ligand free structure of Cytochrome P450 TbtJ1 分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Gober, J.G, Ghodge, S.V, Brustad, E.M, Bowers, A.A. 登録日 2017-05-22 公開日 2017-06-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.411 Å) 主引用文献 P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides. ACS Chem. Biol., 12, 2017
5GWE	cytochrome P450 CREJ 分子名称: (4-methylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Dong, S, liu, X, Wang, X, Feng, Y. 登録日 2016-09-11 公開日 2017-07-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XJN	cytochrome P450 CREJ in complex with (4-ethylphenyl) dihydrogen phosphate 分子名称: (4-ethylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Dong, S, Du, L, Li, S, Feng, Y. 登録日 2017-05-03 公開日 2017-07-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UHU	Solution conformation of cytochrome P450 MycG with mycinamicin IV bound 分子名称: MYCINAMICIN IV, Mycinamicin IV hydroxylase/epoxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Pochapsky, T.C, Tietz, D.R. 登録日 2017-01-12 公開日 2017-08-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry, 56, 2017
5WK7	P450cam mutant R186A 分子名称: 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Batabyal, D, Poulos, T.L. 登録日 2017-07-24 公開日 2017-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.983 Å) 主引用文献 Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
5WK9	R186AP450cam with CN and camphor 分子名称: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... 著者 Poulos, T.L, Batabyal, D. 登録日 2017-07-24 公開日 2017-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.983 Å) 主引用文献 Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
5W0C	Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex 分子名称: Cytochrome P450 2C9, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Johnson, E.F, Hsu, M.-H. 登録日 2017-05-30 公開日 2017-09-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angew. Chem. Int. Ed. Engl., 56, 2017
5Y1I	The crystal structure of GfsF 分子名称: Cytochrome P450, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Miyanaga, A, Kudo, F, Eguchi, T. 登録日 2017-07-20 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis Chembiochem, 18, 2017
5OFQ	Crystal structure of substrate-free CYP109A2 from Bacillus megaterium 分子名称: Cytochrome P450, PENTAETHYLENE GLYCOL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Jozwik, I.K, Thunnissen, A.M.W.H. 登録日 2017-07-11 公開日 2017-09-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Biochemical and structural characterization of CYP109A2, a vitamin D3 25-hydroxylase from Bacillus megaterium. FEBS J., 284, 2017
5TL8	Naegleria fowleri CYP51-posaconazole complex 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, POSACONAZOLE, ... 著者 Podust, L.M, Jennings, G, Calvet-Alvarez, C, Debnath, A. 登録日 2016-10-10 公開日 2017-10-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structure of the Naegleria fowleri CYP51 at 1.7 Angstroms resolution To be published
5X24	Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules 分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... 著者 Maekawa, K, Adachi, M, Shah, M.B. 登録日 2017-01-30 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56, 2017
5X23	Crystal structure of CYP2C9 genetic variant A477T (*30) in complex with multiple losartan molecules 分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... 著者 Maekawa, K, Adachi, M, Shah, M.B. 登録日 2017-01-30 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56, 2017
5XXI	Crystal structure of CYP2C9 in complex with multiple losartan molecules 分子名称: Cytochrome P450 2C9, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Maekawa, K, Adachi, M, Shah, M.B. 登録日 2017-07-04 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56, 2017
5VEU	Human Cytochrome P450 3A5 (CYP3A5) 分子名称: Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Hsu, M.-H, Johnson, E.F. 登録日 2017-04-05 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5. Mol. Pharmacol., 93, 2018

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