5XXI
Crystal structure of CYP2C9 in complex with multiple losartan molecules
Summary for 5XXI
Entry DOI | 10.2210/pdb5xxi/pdb |
Related | 5X23 5X24 |
Descriptor | Cytochrome P450 2C9, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, cyp2c9, p450 2c9 |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11712 |
Total number of polymer chains | 1 |
Total formula weight | 54687.44 |
Authors | Maekawa, K.,Adachi, M.,Shah, M.B. (deposition date: 2017-07-04, release date: 2017-10-25, Last modification date: 2023-11-22) |
Primary citation | Maekawa, K.,Adachi, M.,Matsuzawa, Y.,Zhang, Q.,Kuroki, R.,Saito, Y.,Shah, M.B. Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56:5476-5480, 2017 Cited by PubMed: 28972767DOI: 10.1021/acs.biochem.7b00795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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