5XXI
Crystal structure of CYP2C9 in complex with multiple losartan molecules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 2C9 | polymer | 463 | 52763.1 | 1 | UniProt (P11712) Pfam (PF00067) | Homo sapiens (Human) | (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase |
| 2 | B, C, D (A) | [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | non-polymer | 422.9 | 3 | Chemie (LSN) | |||
| 3 | E (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 4 | F (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | G (A) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 28 - 490 (UniProt: P11712)
| PDB | External Database | Details |
|---|---|---|
| Ile 490 | Val 490 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52763.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1924.3 | |
| All* | Total formula weight | 54687.4 |
