5VEU
Human Cytochrome P450 3A5 (CYP3A5)
Summary for 5VEU
| Entry DOI | 10.2210/pdb5veu/pdb |
| Related PRD ID | PRD_001001 |
| Descriptor | Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR (3 entities in total) |
| Functional Keywords | inhibitor, complex, cytochrome p450, ritonavir, cyp3a5, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 12 |
| Total formula weight | 667911.71 |
| Authors | Hsu, M.-H.,Johnson, E.F. (deposition date: 2017-04-05, release date: 2017-11-15, Last modification date: 2023-10-04) |
| Primary citation | Hsu, M.H.,Savas, U.,Johnson, E.F. The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5. Mol. Pharmacol., 93:14-24, 2018 Cited by PubMed: 29093019DOI: 10.1124/mol.117.109744 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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