Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5VEU

Human Cytochrome P450 3A5 (CYP3A5)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0070330	molecular_function	aromatase activity
A	0070989	biological_process	oxidative demethylation
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
B	0002933	biological_process	lipid hydroxylation
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0008401	molecular_function	retinoic acid 4-hydroxylase activity
B	0009822	biological_process	alkaloid catabolic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0042178	biological_process	xenobiotic catabolic process
B	0042572	biological_process	retinol metabolic process
B	0042573	biological_process	retinoic acid metabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046222	biological_process	aflatoxin metabolic process
B	0046872	molecular_function	metal ion binding
B	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
B	0070330	molecular_function	aromatase activity
B	0070989	biological_process	oxidative demethylation
B	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
C	0002933	biological_process	lipid hydroxylation
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008210	biological_process	estrogen metabolic process
C	0008401	molecular_function	retinoic acid 4-hydroxylase activity
C	0009822	biological_process	alkaloid catabolic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042572	biological_process	retinol metabolic process
C	0042573	biological_process	retinoic acid metabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046222	biological_process	aflatoxin metabolic process
C	0046872	molecular_function	metal ion binding
C	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
C	0070330	molecular_function	aromatase activity
C	0070989	biological_process	oxidative demethylation
C	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
D	0002933	biological_process	lipid hydroxylation
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008210	biological_process	estrogen metabolic process
D	0008401	molecular_function	retinoic acid 4-hydroxylase activity
D	0009822	biological_process	alkaloid catabolic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0042178	biological_process	xenobiotic catabolic process
D	0042572	biological_process	retinol metabolic process
D	0042573	biological_process	retinoic acid metabolic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046222	biological_process	aflatoxin metabolic process
D	0046872	molecular_function	metal ion binding
D	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
D	0070330	molecular_function	aromatase activity
D	0070989	biological_process	oxidative demethylation
D	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
E	0002933	biological_process	lipid hydroxylation
E	0004497	molecular_function	monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006805	biological_process	xenobiotic metabolic process
E	0008202	biological_process	steroid metabolic process
E	0008210	biological_process	estrogen metabolic process
E	0008401	molecular_function	retinoic acid 4-hydroxylase activity
E	0009822	biological_process	alkaloid catabolic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0042178	biological_process	xenobiotic catabolic process
E	0042572	biological_process	retinol metabolic process
E	0042573	biological_process	retinoic acid metabolic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0046222	biological_process	aflatoxin metabolic process
E	0046872	molecular_function	metal ion binding
E	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
E	0070330	molecular_function	aromatase activity
E	0070989	biological_process	oxidative demethylation
E	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
F	0002933	biological_process	lipid hydroxylation
F	0004497	molecular_function	monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006805	biological_process	xenobiotic metabolic process
F	0008202	biological_process	steroid metabolic process
F	0008210	biological_process	estrogen metabolic process
F	0008401	molecular_function	retinoic acid 4-hydroxylase activity
F	0009822	biological_process	alkaloid catabolic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0042178	biological_process	xenobiotic catabolic process
F	0042572	biological_process	retinol metabolic process
F	0042573	biological_process	retinoic acid metabolic process
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0046222	biological_process	aflatoxin metabolic process
F	0046872	molecular_function	metal ion binding
F	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
F	0070330	molecular_function	aromatase activity
F	0070989	biological_process	oxidative demethylation
F	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
G	0002933	biological_process	lipid hydroxylation
G	0004497	molecular_function	monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006805	biological_process	xenobiotic metabolic process
G	0008202	biological_process	steroid metabolic process
G	0008210	biological_process	estrogen metabolic process
G	0008401	molecular_function	retinoic acid 4-hydroxylase activity
G	0009822	biological_process	alkaloid catabolic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
G	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0042178	biological_process	xenobiotic catabolic process
G	0042572	biological_process	retinol metabolic process
G	0042573	biological_process	retinoic acid metabolic process
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0046222	biological_process	aflatoxin metabolic process
G	0046872	molecular_function	metal ion binding
G	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
G	0070330	molecular_function	aromatase activity
G	0070989	biological_process	oxidative demethylation
G	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
H	0002933	biological_process	lipid hydroxylation
H	0004497	molecular_function	monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006805	biological_process	xenobiotic metabolic process
H	0008202	biological_process	steroid metabolic process
H	0008210	biological_process	estrogen metabolic process
H	0008401	molecular_function	retinoic acid 4-hydroxylase activity
H	0009822	biological_process	alkaloid catabolic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
H	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0042178	biological_process	xenobiotic catabolic process
H	0042572	biological_process	retinol metabolic process
H	0042573	biological_process	retinoic acid metabolic process
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0046222	biological_process	aflatoxin metabolic process
H	0046872	molecular_function	metal ion binding
H	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
H	0070330	molecular_function	aromatase activity
H	0070989	biological_process	oxidative demethylation
H	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
I	0002933	biological_process	lipid hydroxylation
I	0004497	molecular_function	monooxygenase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0006805	biological_process	xenobiotic metabolic process
I	0008202	biological_process	steroid metabolic process
I	0008210	biological_process	estrogen metabolic process
I	0008401	molecular_function	retinoic acid 4-hydroxylase activity
I	0009822	biological_process	alkaloid catabolic process
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
I	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
I	0019825	molecular_function	oxygen binding
I	0020037	molecular_function	heme binding
I	0042178	biological_process	xenobiotic catabolic process
I	0042572	biological_process	retinol metabolic process
I	0042573	biological_process	retinoic acid metabolic process
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0046222	biological_process	aflatoxin metabolic process
I	0046872	molecular_function	metal ion binding
I	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
I	0070330	molecular_function	aromatase activity
I	0070989	biological_process	oxidative demethylation
I	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
J	0002933	biological_process	lipid hydroxylation
J	0004497	molecular_function	monooxygenase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0006805	biological_process	xenobiotic metabolic process
J	0008202	biological_process	steroid metabolic process
J	0008210	biological_process	estrogen metabolic process
J	0008401	molecular_function	retinoic acid 4-hydroxylase activity
J	0009822	biological_process	alkaloid catabolic process
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
J	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0042178	biological_process	xenobiotic catabolic process
J	0042572	biological_process	retinol metabolic process
J	0042573	biological_process	retinoic acid metabolic process
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0046222	biological_process	aflatoxin metabolic process
J	0046872	molecular_function	metal ion binding
J	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
J	0070330	molecular_function	aromatase activity
J	0070989	biological_process	oxidative demethylation
J	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
K	0002933	biological_process	lipid hydroxylation
K	0004497	molecular_function	monooxygenase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0006805	biological_process	xenobiotic metabolic process
K	0008202	biological_process	steroid metabolic process
K	0008210	biological_process	estrogen metabolic process
K	0008401	molecular_function	retinoic acid 4-hydroxylase activity
K	0009822	biological_process	alkaloid catabolic process
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
K	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0042178	biological_process	xenobiotic catabolic process
K	0042572	biological_process	retinol metabolic process
K	0042573	biological_process	retinoic acid metabolic process
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0046222	biological_process	aflatoxin metabolic process
K	0046872	molecular_function	metal ion binding
K	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
K	0070330	molecular_function	aromatase activity
K	0070989	biological_process	oxidative demethylation
K	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
L	0002933	biological_process	lipid hydroxylation
L	0004497	molecular_function	monooxygenase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0006805	biological_process	xenobiotic metabolic process
L	0008202	biological_process	steroid metabolic process
L	0008210	biological_process	estrogen metabolic process
L	0008401	molecular_function	retinoic acid 4-hydroxylase activity
L	0009822	biological_process	alkaloid catabolic process
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
L	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
L	0019825	molecular_function	oxygen binding
L	0020037	molecular_function	heme binding
L	0042178	biological_process	xenobiotic catabolic process
L	0042572	biological_process	retinol metabolic process
L	0042573	biological_process	retinoic acid metabolic process
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0046222	biological_process	aflatoxin metabolic process
L	0046872	molecular_function	metal ion binding
L	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
L	0070330	molecular_function	aromatase activity
L	0070989	biological_process	oxidative demethylation
L	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue HEM A 601

Chain	Residue
A	ARG105
A	PRO433
A	PHE434
A	GLY435
A	ARG439
A	CYS441
A	ILE442
A	ALA447
A	RIT602
A	ILE118
A	TRP126
A	ARG130
A	PHE302
A	ALA305
A	THR309
A	VAL313
A	ARG375

site_id	AC2
Number of Residues	11
Details	binding site for residue RIT A 602

Chain	Residue
A	SER119
A	LEU120
A	PHE210
A	PHE213
A	PHE215
A	PHE220
A	PHE241
A	PHE304
A	THR309
A	ALA370
A	HEM601

site_id	AC3
Number of Residues	18
Details	binding site for residue HEM B 601

Chain	Residue
B	ARG105
B	ILE118
B	TRP126
B	ARG130
B	PHE302
B	ALA305
B	THR309
B	VAL369
B	LEU373
B	ARG375
B	PRO433
B	PHE434
B	ARG439
B	ASN440
B	CYS441
B	ILE442
B	ALA447
B	RIT602

site_id	AC4
Number of Residues	12
Details	binding site for residue RIT B 602

Chain	Residue
B	ARG106
B	LEU120
B	PHE210
B	PHE215
B	PHE241
B	ILE301
B	PHE304
B	ALA370
B	ILE371
B	GLU374
B	GLY480
B	HEM601

site_id	AC5
Number of Residues	17
Details	binding site for residue HEM C 601

Chain	Residue
C	ARG105
C	ILE118
C	TRP126
C	ARG130
C	PHE302
C	ALA305
C	THR309
C	VAL313
C	ALA370
C	ARG375
C	PRO433
C	PHE434
C	ARG439
C	ASN440
C	CYS441
C	ILE442
C	ALA447

site_id	AC6
Number of Residues	18
Details	binding site for residue HEM D 601

Chain	Residue
D	ARG105
D	ILE118
D	SER119
D	TRP126
D	ARG130
D	PHE302
D	ALA305
D	THR309
D	VAL313
D	LEU373
D	ARG375
D	PRO433
D	PHE434
D	ARG439
D	CYS441
D	ILE442
D	PHE446
D	ALA447

site_id	AC7
Number of Residues	17
Details	binding site for residue HEM E 601

Chain	Residue
E	THR309
E	VAL313
E	ALA370
E	LEU373
E	ARG375
E	PRO433
E	PHE434
E	ARG439
E	CYS441
E	ILE442
E	MET451
E	ARG105
E	ILE118
E	TRP126
E	ARG130
E	PHE302
E	ALA305

site_id	AC8
Number of Residues	16
Details	binding site for residue HEM F 601

Chain	Residue
F	ARG105
F	ILE118
F	TRP126
F	ARG130
F	PHE302
F	ALA305
F	GLY306
F	THR309
F	VAL313
F	ARG375
F	PRO433
F	PHE434
F	ARG439
F	CYS441
F	ILE442
F	ALA447

site_id	AC9
Number of Residues	17
Details	binding site for residue HEM G 601

Chain	Residue
G	ARG105
G	ILE118
G	TRP126
G	ARG130
G	PHE302
G	ALA305
G	THR309
G	VAL313
G	ARG375
G	PRO433
G	PHE434
G	GLY435
G	ARG439
G	ASN440
G	CYS441
G	ILE442
G	ALA447

site_id	AD1
Number of Residues	17
Details	binding site for residue HEM H 601

Chain	Residue
H	ARG105
H	ILE118
H	TRP126
H	ARG130
H	PHE302
H	ALA305
H	THR309
H	VAL369
H	LEU373
H	ARG375
H	PRO433
H	PHE434
H	ARG439
H	CYS441
H	ILE442
H	ALA447
H	RIT602

site_id	AD2
Number of Residues	15
Details	binding site for residue RIT H 602

Chain	Residue
H	ARG105
H	ARG106
H	LEU120
H	PHE213
H	GLY214
H	PHE220
H	LEU240
H	ILE301
H	PHE304
H	ALA305
H	THR309
H	GLU374
H	GLY480
H	LEU481
H	HEM601

site_id	AD3
Number of Residues	18
Details	binding site for residue HEM I 601

Chain	Residue
I	ARG105
I	ILE118
I	TRP126
I	ARG130
I	PHE302
I	ALA305
I	GLY306
I	THR309
I	VAL313
I	ALA370
I	ARG375
I	PRO433
I	PHE434
I	ARG439
I	ASN440
I	CYS441
I	ILE442
I	ALA447

site_id	AD4
Number of Residues	18
Details	binding site for residue HEM J 601

Chain	Residue
J	ARG105
J	ILE118
J	TRP126
J	ARG130
J	ALA305
J	THR309
J	VAL313
J	ALA370
J	LEU373
J	ARG375
J	PRO433
J	PHE434
J	GLY435
J	ARG439
J	ASN440
J	CYS441
J	ILE442
J	ALA447

site_id	AD5
Number of Residues	19
Details	binding site for residue HEM K 601

Chain	Residue
K	ARG105
K	ILE118
K	TRP126
K	ARG130
K	PHE302
K	ALA305
K	THR309
K	VAL313
K	VAL369
K	LEU373
K	ARG375
K	PRO433
K	PHE434
K	GLY435
K	ARG439
K	ASN440
K	CYS441
K	ILE442
K	ALA447

site_id	AD6
Number of Residues	18
Details	binding site for residue HEM L 601

Chain	Residue
L	ARG105
L	ILE118
L	SER119
L	TRP126
L	ARG130
L	ILE184
L	PHE302
L	ALA305
L	THR309
L	ALA370
L	LEU373
L	ARG375
L	PRO433
L	PHE434
L	ARG439
L	ASN440
L	CYS441
L	ALA447

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGtGPRNCIG

Chain	Residue	Details
A	PHE434-GLY443

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS441
J	CYS441
K	CYS441
L	CYS441
B	CYS441
C	CYS441
D	CYS441
E	CYS441
F	CYS441
G	CYS441
H	CYS441
I	CYS441

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)