PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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3L1Z	Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme 分子名称: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3 著者 Benirschke, R, Thompson, J.R, Mer, G. 登録日 2009-12-14 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4. Structure, 18, 2010
1JSV	The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide 分子名称: 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 著者 Watenpaugh, K.D, Kelley, L.C. 登録日 2001-08-19 公開日 2001-08-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism J.Biol.Chem., 276, 2001
1JT4	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L) 分子名称: FORMIC ACID, acidic fibroblast growth factor 著者 Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. 登録日 2001-08-20 公開日 2001-12-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Protein Sci., 10, 2001
1JT7	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L) 分子名称: FORMIC ACID, SULFATE ION, acidic fibroblast growth factor 著者 Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. 登録日 2001-08-20 公開日 2001-12-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Protein Sci., 10, 2001
7K6R	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027 分子名称: 1,2-ETHANEDIOL, 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one, Nucleosome-remodeling factor subunit BPTF 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
3L1P	POU protein:DNA complex 分子名称: DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ... 著者 Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M. 登録日 2009-12-14 公開日 2010-12-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A unique Oct4 interface is crucial for reprogramming to pluripotency Nat.Cell Biol., 15, 2013
7JVU	Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA 分子名称: 1,2-ETHANEDIOL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5004766 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
1KBH	Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR 分子名称: CREB-BINDING PROTEIN, nuclear receptor coactivator 著者 Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E. 登録日 2001-11-06 公開日 2002-02-06 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature, 415, 2002
3LFQ	Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor 分子名称: Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide 著者 Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. 登録日 2010-01-18 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
1K8K	Crystal Structure of Arp2/3 Complex 分子名称: ACTIN-LIKE PROTEIN 2, ACTIN-LIKE PROTEIN 3, ARP2/3 COMPLEX 16 KDA SUBUNIT, ... 著者 Robinson, R.C, Turbedsky, K, Kaiser, D.A, Higgs, H.N, Marchand, J.-B, Choe, S, Pollard, T.D. 登録日 2001-10-24 公開日 2001-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Arp2/3 Complex Science, 294, 2001
7JVV	Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate 分子名称: 1,2-ETHANEDIOL, ACE-ARG-HIS-ALY-ALY-MCM, GLYCEROL, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
1JT5	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L) 分子名称: SULFATE ION, acidic fibroblast growth factor 著者 Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. 登録日 2001-08-20 公開日 2001-12-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Protein Sci., 10, 2001
1DUX	ELK-1/DNA STRUCTURE REVEALS HOW RESIDUES DISTAL FROM DNA-BINDING SURFACE AFFECT DNA-RECOGNITION 分子名称: DNA (5'-D(*AP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*T)-3'), ETS-DOMAIN PROTEIN ELK-1 著者 Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. 登録日 2000-01-19 公開日 2000-04-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. Nat.Struct.Biol., 7, 2000
3MSV	The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor 分子名称: Nuclear import adaptor, Nro1 著者 Yeh, T.L, Amzel, L.M, Bianchet, M.A. 登録日 2010-04-29 公開日 2011-04-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Structure, 19, 2011
7JSA	Crystal structure of the DNA binding domain of human transcription factor ERF in the reduced form, in complex with double-stranded DNA ACCGGAAGTG 分子名称: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF 著者 Hou, C, Tsodikov, O.V. 登録日 2020-08-14 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Insight into the DNA Binding Function of Transcription Factor ERF. Biochemistry, 2020
1JPY	Crystal structure of IL-17F 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Hymowitz, S.G, Filvaroff, E.H, Yin, J, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, R, Pan, G, Gurney, A.L, de Vos, A.M, Starovasnik, M.A. 登録日 2001-08-03 公開日 2001-09-28 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J., 20, 2001
7JVW	Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... 著者 Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M. 登録日 2020-08-24 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.40301776 Å) 主引用文献 Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213, 2020
1DZ7	Solution structure of the a-subunit of human chorionic gonadotropin [modeled without carbohydrate residues] 分子名称: CHORIONIC GONADOTROPIN 著者 Erbel, P.J.A, Karimi-Nejad, Y, De Beer, T, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G. 登録日 2000-02-18 公開日 2000-02-29 最終更新日 2019-10-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the alpha-subunit of human chorionic gonadotropin. Eur.J.Biochem., 260, 1999
7K6S	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 4 (SKT1174) 分子名称: (7-amino-3,4-dihydroquinolin-1(2H)-yl)(cyclopropyl)methanone, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Chan, A, Schonbrunn, E. 登録日 2020-09-21 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem., 18, 2020
7KDW	Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to Compound 6 (HZ01052) 分子名称: 1,2-ETHANEDIOL, Nucleosome-remodeling factor subunit BPTF, cyclopropyl[7-({2-[(prop-2-yn-1-yl)amino]pyrimidin-4-yl}amino)-3,4-dihydroquinolin-1(2H)-yl]methanone 著者 Chan, A, Schonbrunn, E. 登録日 2020-10-09 公開日 2020-12-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development Organic and Biomolecular Chemistry, 18(27), 2020
1FIN	CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE 2 著者 Jeffrey, P.D, Russo, A.A, Pavletich, N.P. 登録日 1996-07-14 公開日 1997-01-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature, 376, 1995
1JTC	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F) 分子名称: FORMIC ACID, acidic fibroblast growth factor 著者 Brych, S.R, Blaber, S.I, Logan, T.M, Blaber, M. 登録日 2001-08-20 公開日 2001-12-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Protein Sci., 10, 2001
1JOW	Crystal structure of a complex of human CDK6 and a viral cyclin 分子名称: CELL DIVISION PROTEIN KINASE 6, CYCLIN HOMOLOG 著者 Schulze-Gahmen, U, Kim, S.H. 登録日 2001-07-31 公開日 2002-02-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for CDK6 activation by a virus-encoded cyclin. Nat.Struct.Biol., 9, 2002
1FQ1	CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN-DEPENDENT KINASE INHIBITOR 3, ... 著者 Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. 登録日 2000-09-01 公開日 2001-05-09 最終更新日 2018-03-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol.Cell, 7, 2001
3M1S	Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 分子名称: Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole 著者 Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. 登録日 2010-03-05 公開日 2010-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.134 Å) 主引用文献 Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta J.Biol.Inorg.Chem., 16, 2011

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