5KTD
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![BU of 5ktd by Molmil](/molmil-images/mine/5ktd) | FdhC with bound products: Coenzyme A and dTDP-3-amino-3,6-dideoxy-d-glucose | 分子名称: | 1,2-ETHANEDIOL, COENZYME A, FdhC, ... | 著者 | Salinger, A.J, Thoden, J.B, Holden, H.M. | 登録日 | 2016-07-11 | 公開日 | 2016-07-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily. Biochemistry, 55, 2016
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6X18
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![BU of 6x18 by Molmil](/molmil-images/mine/6x18) | GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor | 分子名称: | Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Zhang, X, Danev, R. | 登録日 | 2020-05-18 | 公開日 | 2020-09-09 | 最終更新日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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4UEK
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![BU of 4uek by Molmil](/molmil-images/mine/4uek) | Galactitol-1-phosphate 5-dehydrogenase from E. coli with Tris within the active site. | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE, ZINC ION | 著者 | Benavente, R, Esteban-Torres, M, Kohring, G.W, Cortes-Cabrera, A, Gago, F, Acebron, I, de las Rivas, B, Munoz, R, Mancheno, J.M. | 登録日 | 2014-12-18 | 公開日 | 2015-07-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Enantioselective Oxidation of Galactitol 1-Phosphate by Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli Acta Crystallogr.,Sect.D, 71, 2015
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5L45
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![BU of 5l45 by Molmil](/molmil-images/mine/5l45) | polyketide ketoreductase SimC7 - apo crystal form 2 | 分子名称: | GLYCEROL, SimC7, TETRAETHYLENE GLYCOL | 著者 | Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J. | 登録日 | 2016-05-25 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23, 2016
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2AJI
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![BU of 2aji by Molmil](/molmil-images/mine/2aji) | Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase complexes with isoleucine | 分子名称: | ISOLEUCINE, Leucyl-tRNA synthetase | 著者 | Liu, Y, Liao, J, Zhu, B, Wang, E.D, Ding, J. | 登録日 | 2005-08-02 | 公開日 | 2006-01-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination Biochem.J., 394, 2006
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6WOB
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![BU of 6wob by Molmil](/molmil-images/mine/6wob) | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 4-diphosphoinositol pentakisphosphate (4-IP7), Mg, and Fluoride ion | 分子名称: | (1S,2R,3S,4S,5S,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | 著者 | Zong, G.N, Wang, H.C, Shears, B.S. | 登録日 | 2020-04-24 | 公開日 | 2021-03-03 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. Faseb J., 35, 2021
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6X3E
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![BU of 6x3e by Molmil](/molmil-images/mine/6x3e) | hEAAT3-Asymmetric-1o2i | 分子名称: | ASPARTIC ACID, Excitatory amino acid transporter 3, SODIUM ION | 著者 | Qiu, B, Matthies, D, Boudker, O. | 登録日 | 2020-05-21 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
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2YXG
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4V2X
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![BU of 4v2x by Molmil](/molmil-images/mine/4v2x) | High resolution structure of the full length tri-modular endo-beta-1, 4-glucanase B (Cel5B) from Bacillus halodurans | 分子名称: | ACETATE ION, CACODYLATE ION, CALCIUM ION, ... | 著者 | Venditto, I, Santos, H, Ferreira, L.M.A, Sakka, K, Fontes, C.M.G.A, Najmudin, S. | 登録日 | 2014-10-15 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Family 46 Carbohydrate-Binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and Beta-1,3-1,4-Glucans Through Distinct Mechanisms. J.Biol.Chem., 290, 2015
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5KKM
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![BU of 5kkm by Molmil](/molmil-images/mine/5kkm) | Con-Vc11-22 | 分子名称: | O2_contryphan_Vc1 prepropeptide | 著者 | Chittoor, B, Krishnarjuna, B, MacRaild, C.A, Robinson, S.D. | 登録日 | 2016-06-22 | 公開日 | 2017-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Single Disulfide-Directed beta-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry, 56, 2017
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6DF6
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![BU of 6df6 by Molmil](/molmil-images/mine/6df6) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab | 分子名称: | (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, GLYCEROL | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | 登録日 | 2018-05-14 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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4V2S
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![BU of 4v2s by Molmil](/molmil-images/mine/4v2s) | Crystal structure of Hfq in complex with the sRNA RydC | 分子名称: | RNA-BINDING PROTEIN HFQ, RYDC | 著者 | Dimastrogiovanni, D, Frohlich, K.S, Bruce, H.A, Bandyra, K.J, Hohensee, S, Vogel, J, Luisi, B.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | Recognition of the small regulatory RNA RydC by the bacterial Hfq protein. Elife, 3, 2014
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6DTE
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![BU of 6dte by Molmil](/molmil-images/mine/6dte) | GlcNAc-inspired cyclophellitol bound to NagZ | 分子名称: | 2,2,2-trifluoro-N-[(1R,2R,3R,4R,5R,6R)-2,3,5,6-tetrahydroxy-4-(hydroxymethyl)cyclohexyl]acetamide, Beta-hexosaminidase | 著者 | Mark, B.L, Winogrodzki, J.L. | 登録日 | 2018-06-15 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.929 Å) | 主引用文献 | A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa. Chem. Commun. (Camb.), 54, 2018
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5LCH
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![BU of 5lch by Molmil](/molmil-images/mine/5lch) | VIM-2 metallo-beta-lactamase in complex with (S)-1-allyl-2-(3-methoxyphenyl)-3-oxoisoindoline-4-carboxylic acid (compound 42) | 分子名称: | (1~{S})-2-(3-methoxyphenyl)-3-oxidanylidene-1-prop-2-enyl-1~{H}-isoindole-4-carboxylic acid, Metallo-beta-lactamase VIM-2, ZINC ION | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2016-06-21 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | NMR-filtered virtual screening leads to non-metal chelating metallo-beta-lactamase inhibitors. Chem Sci, 8, 2017
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8SDI
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8SDJ
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4V40
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![BU of 4v40 by Molmil](/molmil-images/mine/4v40) | BETA-GALACTOSIDASE | 分子名称: | BETA-GALACTOSIDASE, MAGNESIUM ION | 著者 | Jacobson, R.H, Zhang, X, Dubose, R.F, Matthews, B.W. | 登録日 | 1994-07-18 | 公開日 | 2014-07-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Three-dimensional structure of beta-galactosidase from E. coli. Nature, 369, 1994
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8SDE
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6DSI
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5LCA
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![BU of 5lca by Molmil](/molmil-images/mine/5lca) | VIM-2 metallo-beta-lactamase in complex with 3-oxo-2-(3-(trifluoromethyl)phenyl)isoindoline-4-carboxylic acid (compound 17) | 分子名称: | 3-oxidanylidene-2-[3-(trifluoromethyl)phenyl]-1~{H}-isoindole-4-carboxylic acid, GLYCEROL, Metallo-beta-lactamase VIM-2, ... | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2016-06-20 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | NMR-filtered virtual screening leads to non-metal chelating metallo-beta-lactamase inhibitors. Chem Sci, 8, 2017
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5LD2
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![BU of 5ld2 by Molmil](/molmil-images/mine/5ld2) | Cryo-EM structure of RecBCD+DNA complex revealing activated nuclease domain | 分子名称: | Fork-Hairpin DNA (70-MER), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Wilkinson, M, Chaban, Y, Wigley, D.B. | 登録日 | 2016-06-23 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | Mechanism for nuclease regulation in RecBCD. Elife, 5, 2016
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2B2X
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![BU of 2b2x by Molmil](/molmil-images/mine/2b2x) | VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab | 分子名称: | Antibody AQC2 Fab, Integrin alpha-1, MAGNESIUM ION | 著者 | Clark, L.A, Boriack-Sjodin, P.A, Eldredge, J, Fitch, C, Friedman, B, Hanf, K.J, Jarpe, M, Liparoto, S.F, Li, Y, Lugovskoy, A. | 登録日 | 2005-09-19 | 公開日 | 2006-04-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design Protein Sci., 15, 2006
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6D4Q
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![BU of 6d4q by Molmil](/molmil-images/mine/6d4q) | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 14 (VCC900455) | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, cycloheptyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone | 著者 | Ascher, D.B, Pacitto, A, Blundell, T.L. | 登録日 | 2018-04-18 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019
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8STB
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![BU of 8stb by Molmil](/molmil-images/mine/8stb) | The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX | 分子名称: | CHLORIDE ION, GLYCEROL, Glyoxalase, ... | 著者 | Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B. | 登録日 | 2023-05-09 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | The crystal structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX. To Be Published
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8STL
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![BU of 8stl by Molmil](/molmil-images/mine/8stl) | Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha | 分子名称: | Nanobody PIK3_Nb16, SULFATE ION | 著者 | Nwafor, J.N, Srinivasan, L, Chen, Z, Gabelli, S.B, Iheanacho, A, Alzogaray, V, Klinke, S. | 登録日 | 2023-05-10 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Development of isoform specific nanobodies for Class I PI3Ks To be published
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