PDB: 183105 件ウェブページステータス検索Chemie searchBIRD

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8FCR	Cryo-EM structure of p97:UBXD1 H4-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8D81	Cereblon~DDB1 bound to Pomalidomide 分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8FCQ	Cryo-EM structure of p97:UBXD1 PUB-in state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
8FCM	Cryo-EM structure of p97:UBXD1 open state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6 著者 Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R. 登録日 2022-12-01 公開日 2023-06-21 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat.Struct.Mol.Biol., 30, 2023
6PRU	Photoconvertible crystals of PixJ from Thermosynechococcus elongatus 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Burgie, E.S, Clinger, J.A, Miller, M.D, Phillips Jr, G.N, Vierstra, R.D. 登録日 2019-07-11 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.539 Å) 主引用文献 Photoreversible interconversion of a phytochrome photosensory module in the crystalline state. Proc.Natl.Acad.Sci.USA, 117, 2020
8D7W	Cereblon~DDB1 bound to CC-92480 with DDB1 in the hinged conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8CVP	Cereblon-DDB1 in the Apo form 分子名称: DNA damage-binding protein 1, Protein cereblon, ZINC ION 著者 Watson, E.R, Lander, G.C. 登録日 2022-05-18 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8D7V	Cereblon~DDB1 bound to CC-92480 with DDB1 in the twisted conformation 分子名称: DNA damage-binding protein 1, Mezigdomide, Protein cereblon, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
8G57	Structure of nucleosome-bound Sirtuin 6 deacetylase 分子名称: DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... 著者 Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. 登録日 2023-02-11 公開日 2023-04-26 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Cryo-EM structure of the human Sirtuin 6-nucleosome complex. Sci Adv, 9, 2023
4Y81	Yeast 20S proteasome in complex with Ac-PAY-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAY-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
8QZ3	Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ... 著者 Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2023-10-26 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
4Y8H	Yeast 20S proteasome in complex with N3-APAL-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
6FQM	3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA 分子名称: 7-[(3~{S})-3-azanylpyrrolidin-1-yl]-5-cyclopropyl-8-fluoranyl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*T)-3'), DNA gyrase subunit A, ... 著者 Bax, B.D, Germe, T, Basque, E, Maxwell, A. 登録日 2018-02-14 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Res., 46, 2018
6T21	N-terminal domain of EcoKMcrA restriction endonuclease (NEco) in complex with T5mCGA target sequence 分子名称: 5-methylcytosine-specific restriction enzyme A, DNA (5'-D(*GP*AP*AP*TP*(5CM)P*GP*AP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*TP*(5CM)P*GP*AP*TP*TP*C)-3') 著者 Slyvka, A, Zagorskaite, E, Czapinska, H, Sasnauskas, G, Bochtler, M. 登録日 2019-10-07 公開日 2019-10-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping. Nucleic Acids Res., 47, 2019
4Y8J	Yeast 20S proteasome in complex with Ac-LLL-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PLL-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
6NB1	Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06 分子名称: ATP-dependent Clp protease proteolytic subunit, GLYCEROL, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide 著者 Mabanglo, M.F, Houry, W.A, Eger, B.T, Bryson, S, Pai, E.F. 登録日 2018-12-06 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol, 2, 2019
6UXO	Crystal structure of BAK core domain BH3-groove-dimer in complex with DDM 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Bcl-2 homologous antagonist/killer, ... 著者 Cowan, A.D, Colman, P.M, Czabotar, P.E. 登録日 2019-11-07 公開日 2020-09-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 BAK core dimers bind lipids and can be bridged by them. Nat.Struct.Mol.Biol., 27, 2020
6PXV	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. 分子名称: Insulin, Insulin receptor 著者 Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. 登録日 2019-07-27 公開日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
8GJH	Salmonella ArnA 分子名称: Bifunctional polymyxin resistance protein ArnA, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID 著者 Sousa, M.C, Mitchell, M.E, Gatzeva-Topalova, P.Z. 登録日 2023-03-15 公開日 2023-08-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry, 62, 2023
7QD1	Structure of the orange carotenoid protein from Planktothrix agardhii binding echinenone in the P21 space group 分子名称: Orange carotenoid-binding protein, beta,beta-caroten-4-one 著者 Andreeva, E.A, Hartmann, E, Schlichting, I, Colletier, J.-P. 登録日 2021-11-26 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: Impact of his-tagging and carotenoid type. Biochim Biophys Acta Bioenerg, 1863, 2022
7QD0	Structure of the orange carotenoid protein from Planktothrix agardhii binding echinenone in the C2 space group 分子名称: ACETATE ION, ARGININE, GLYCEROL, ... 著者 Andreeva, E.A, Hartmann, E, Schlichting, I, Colletier, J.-P. 登録日 2021-11-25 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: Impact of his-tagging and carotenoid type. Biochim Biophys Acta Bioenerg, 1863, 2022
7QD2	Structure of the orange carotenoid protein from Planktothrix agardhii binding canthaxanthin in the P21 space group 分子名称: ACETATE ION, GLYCEROL, Orange carotenoid-binding protein, ... 著者 Andreeva, E.A, Hartmann, E, Schlichting, I, Colletier, J.-P. 登録日 2021-11-26 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: Impact of his-tagging and carotenoid type. Biochim Biophys Acta Bioenerg, 1863, 2022
7OJK	Lassa virus L protein bound to the distal promoter duplex [DISTAL-PROMOTER] 分子名称: 3' RNA, 5' RNA, RNA-directed RNA polymerase L, ... 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-16 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
5N0A	Crystal structure of A259C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11 分子名称: BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 HEAVY CHAIN, Envelope Glycoprotein E, ... 著者 Vaney, M.C, Rouvinski, A, Guardado-Calvo, P, Sharma, A, Rey, F.A. 登録日 2017-02-02 公開日 2017-06-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. Nat Commun, 8, 2017
7QEI	Structure of human MTHFD2L in complex with TH7299 分子名称: (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 著者 Gustafsson, R, Scaletti, E.R, Stenmark, P. 登録日 2021-12-03 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors. Chemmedchem, 17, 2022

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