6NB1
Crystal structure of Escherichia coli ClpP protease complexed with small molecule activator, ACP1-06
Summary for 6NB1
Entry DOI | 10.2210/pdb6nb1/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | serine protease, antibiotic, hydrolase |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 14 |
Total formula weight | 332803.37 |
Authors | Mabanglo, M.F.,Houry, W.A.,Eger, B.T.,Bryson, S.,Pai, E.F. (deposition date: 2018-12-06, release date: 2019-11-13, Last modification date: 2023-10-11) |
Primary citation | Mabanglo, M.F.,Leung, E.,Vahidi, S.,Seraphim, T.V.,Eger, B.T.,Bryson, S.,Bhandari, V.,Zhou, J.L.,Mao, Y.Q.,Rizzolo, K.,Barghash, M.M.,Goodreid, J.D.,Phanse, S.,Babu, M.,Barbosa, L.R.S.,Ramos, C.H.I.,Batey, R.A.,Kay, L.E.,Pai, E.F.,Houry, W.A. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol, 2:410-410, 2019 Cited by PubMed: 31925204DOI: 10.1038/s42003-019-0656-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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