7NEZ
| Structure of topotecan-bound ABCG2 | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | 登録日 | 2021-02-05 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NFD
| Structure of mitoxantrone-bound ABCG2 | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | 登録日 | 2021-02-06 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NEQ
| Structure of tariquidar-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Kowal, J, Locher, K. | 登録日 | 2021-02-04 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NHL
| VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Crowe-McAuliffe, C, Murina, V, Hauryliuk, V, Wilson, D.N. | 登録日 | 2021-02-10 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. Nat Commun, 12, 2021
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7NHN
| VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Crowe-McAuliffe, C, Turnbull, K.J, Hauryliuk, V, Wilson, D.N. | 登録日 | 2021-02-10 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens. Nat Commun, 12, 2021
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7N59
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7N5A
| Structure of AtAtm3 in the closed conformation | 分子名称: | ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Fan, C, Rees, D.C. | 登録日 | 2021-06-05 | 公開日 | 2022-04-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7N58
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7N5B
| Structure of AtAtm3 in the outward-facing conformation | 分子名称: | ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Fan, C, Rees, D.C. | 登録日 | 2021-06-05 | 公開日 | 2022-04-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
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7MPE
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7MBZ
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7MET
| A. baumannii MsbA in complex with TBT1 decoupler | 分子名称: | 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase | 著者 | Thelot, F, Liao, M. | 登録日 | 2021-04-07 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
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7MEW
| E. coli MsbA in complex with G247 | 分子名称: | (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid, ATP-dependent lipid A-core flippase | 著者 | Thelot, F, Liao, M. | 登録日 | 2021-04-08 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
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7M1P
| Human ABCA4 structure in the unbound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | 著者 | Scortecci, J.F, Van Petegem, F, Molday, R.S. | 登録日 | 2021-03-14 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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7M1Q
| Human ABCA4 structure in complex with N-ret-PE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Retinal-specific phospholipid-transporting ATPase ABCA4, ... | 著者 | Scortecci, J.F, Van Petegem, F, Molday, R.S. | 登録日 | 2021-03-14 | 公開日 | 2021-09-08 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun, 12, 2021
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7O80
| Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | 登録日 | 2021-04-14 | 公開日 | 2021-06-02 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
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7OJ8
| ABCG2 E1S turnover-2 state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | 著者 | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-14 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJH
| ABCG2 topotecan turnover-1 state | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-15 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJI
| ABCG2 topotecan turnover-2 state | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-16 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7VGF
| cryo-EM structure of AMP-PNP bound human ABCB7 | 分子名称: | Iron-sulfur clusters transporter ABCB7, mitochondrial, MAGNESIUM ION, ... | 著者 | Yan, Q, Yang, X, Shen, Y. | 登録日 | 2021-09-16 | 公開日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7. J.Struct.Biol., 214, 2022
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7V8M
| LolCDE-apo in nanodiscs | 分子名称: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE | 著者 | Luo, Q.S, Bei, W.W, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
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7V8I
| LolCD(E171Q)E with bound AMPPNP in nanodiscs | 分子名称: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE, ... | 著者 | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
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7VR5
| Crystal structure of CmABCB1 W114Y/W161Y/W363Y/W364Y/M391W (4WY/M391W) mutant | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DECYL-BETA-D-MALTOPYRANOSIDE, Probable ATP-dependent transporter ycf16 | 著者 | Inoue, Y, Ogawa, H, Kato, H. | 登録日 | 2021-10-21 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy. Protein Sci., 31, 2022
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7V5C
| Cryo-EM structure of the mouse ABCB9 (ADP.BeF3-bound) | 分子名称: | ABC-type oligopeptide transporter ABCB9, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Park, J.G, Kim, S, Jang, E, Choi, S.H, Han, H, Kim, J.W, Ju, S, Min, D.S, Jin, M.S. | 登録日 | 2021-08-17 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase. Nat Commun, 13, 2022
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7V8L
| LolCDE with bound RcsF in nanodiscs | 分子名称: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, ... | 著者 | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
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