PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3H2X	Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22 著者 Tsai, S.J, Sen, U. 登録日 2009-04-14 公開日 2009-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry, 48, 2009
3GN8	X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone 分子名称: DEXAMETHASONE, Glucocorticoid receptor 2, Nuclear receptor coactivator 2 著者 Ortlund, E.A. 登録日 2009-03-16 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An epistatic ratchet constrains the direction of glucocorticoid receptor evolution Nature, 461, 2009
3GUT	Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR 分子名称: HIV-LTR Core Forward Strand, HIV-LTR Core Reverse Strand, Nuclear factor NF-kappa-B p105 subunit, ... 著者 Stroud, J.C, Oltman, A.J, Han, A, Bates, D.L, Chen, L. 登録日 2009-03-30 公開日 2009-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.59 Å) 主引用文献 Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. J.Mol.Biol., 393, 2009
3GJW	PARP complexed with A968427 分子名称: 7-(pyrrolidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one, Poly [ADP-ribose] polymerase 1 著者 Park, C.H. 登録日 2009-03-09 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) Bioorg.Med.Chem.Lett., 19, 2009
3GWS	Crystal Structure of T3-Bound Thyroid Hormone Receptor 分子名称: 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor beta 著者 Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Polikarpov, I, Baxter, J.D, Webb, P. 登録日 2009-04-01 公開日 2009-04-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function J.Mol.Biol., 360, 2006
3GLT	Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine 分子名称: Acetyl-coenzyme A synthetase 2-like, mitochondrial, CARBONATE ION, ... 著者 Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. 登録日 2009-03-12 公開日 2009-06-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
3FDW	Crystal structure of a C2 domain from human synaptotagmin-like protein 4 分子名称: Synaptotagmin-like protein 4 著者 Bonanno, J.B, Rutter, M, Bain, K.T, Miller, S, Romero, R, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2008-11-26 公開日 2008-12-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a C2 domain from human synaptotagmin-like protein 4 To be Published
3FER	Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. 分子名称: ACETIC ACID, Filamin-B 著者 Kuzin, A.P, Abashidze, M, Seetharaman, R, Shastry, R, Sahdev, S, Ciccosanti, C, Xiao, R, Everett, J.K, Huang, Y, Acton, T, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2008-11-30 公開日 2009-01-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. To be Published
3FJ9	Crystal structure of F85W mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. J.Mol.Biol., 393, 2009
3FIL	Structural and energetic determinants for hyperstable variants of GB1 obtained from in-vitro evolution 分子名称: CALCIUM ION, Immunoglobulin G-binding protein G 著者 Max, K.E.A, Heinemann, U. 登録日 2008-12-12 公開日 2009-08-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (0.88 Å) 主引用文献 Dimer Formation of a Stabilized Gbeta1 Variant: A Structural and Energetic Analysis J.Mol.Biol., 391, 2009
3FLN	P38 kinase crystal structure in complex with R1487 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Knapp, M. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published
3FLY	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-[(1-methylethyl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Ghate, M. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published
3EXE	Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex 分子名称: GLYCEROL, MANGANESE (II) ION, POTASSIUM ION, ... 著者 Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. 登録日 2008-10-16 公開日 2008-11-25 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.979 Å) 主引用文献 Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure, 16, 2008
3EYI	The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA 分子名称: 5'-TCGCGCG-3', Z-DNA-binding protein 1 著者 Ha, S.C, Kim, K.K. 登録日 2008-10-21 公開日 2009-01-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA. Proc.Natl.Acad.Sci.USA, 105, 2008
3F31	Crystal Structure of the N-terminal region of AlphaII-spectrin Tetramerization Domain 分子名称: Spectrin alpha chain, brain 著者 Mehboob, S, Santarsiero, B.D, Long, F, Witek, M, Fung, L.W. 登録日 2008-10-30 公開日 2009-10-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the nonerythroid alpha-spectrin tetramerization site reveals differences between erythroid and nonerythroid spectrin tetramer formation. J.Biol.Chem., 285, 2010
3F71	Crystal structure of E18D DJ-1 with oxidized C106 分子名称: Protein DJ-1 著者 Lakshminarasimhan, M, Wilson, M.A. 登録日 2008-11-07 公開日 2008-12-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1. J.Biol.Chem., 284, 2009
3F4X	Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference 分子名称: 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Carbonic anhydrase 2, MERCURY (II) ION, ... 著者 Temperini, C, Cecchi, A, Scozzafava, A, Supuran, C.T. 登録日 2008-11-03 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. J.Med.Chem., 52, 2009
3F7Q	First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 de Pereda, J.M. 登録日 2008-11-10 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes Embo J., 28, 2009
3F66	Human c-Met Kinase in complex with quinoxaline inhibitor 分子名称: 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, Hepatocyte growth factor receptor, ... 著者 Meier, C, Ceska, T. 登録日 2008-11-05 公開日 2008-12-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg.Med.Chem.Lett., 19, 2009
3F96	Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by sarin 分子名称: Platelet-activating factor acetylhydrolase 著者 Samanta, U, Bahnson, B.J. 登録日 2008-11-13 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochem Pharmacol, 78, 2009
3F9N	Crystal structure of chk1 kinase in complex with inhibitor 38 分子名称: 3-(3-chlorophenyl)-2-({(1S)-1-[(6S)-2,8-diazaspiro[5.5]undec-2-ylcarbonyl]pentyl}sulfanyl)quinazolin-4(3H)-one, SULFATE ION, Serine/threonine-protein kinase Chk1 著者 Yan, Y, Munshi, S, Ikuta, M. 登録日 2008-11-14 公開日 2009-01-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of thioquinazolinones, allosteric Chk1 kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3F7P	Crystal structure of a complex between integrin beta4 and plectin 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 de Pereda, J.M. 登録日 2008-11-10 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes Embo J., 28, 2009
3FAA	Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor 分子名称: N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide, PHOSPHATE ION, TGF-beta receptor type-1 著者 Boriack-Sjodin, P.A, Fitch, C. 登録日 2008-11-16 公開日 2009-01-27 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg.Med.Chem.Lett., 19, 2009
3FEA	Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2 at 1.33A 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2 著者 Kallen, J. 登録日 2008-11-28 公開日 2009-01-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes J.Biol.Chem., 284, 2009
3FEI	Design and biological evaluation of novel, balanced dual PPARa/g agonists 分子名称: (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid, Peptide motif 5 of Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor alpha 著者 Benz, J, Grether, U, Gsell, B, Binggeli, A, Hilpert, H, Maerki, H.P, Mohr, P, Ruf, A, Stihle, M, Schlatter, D. 登録日 2008-11-30 公開日 2009-10-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists Chemmedchem, 4, 2009

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