PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3FXY	Acidic Mammalian Chinase, Catalytic Domain 分子名称: Acidic mammalian chitinase 著者 Olland, A.M. 登録日 2009-01-21 公開日 2009-03-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Triad of polar residues implicated in pH specificity of acidic mammalian chitinase. Protein Sci., 18, 2009
3FZP	Crystal structure of PYK2 complexed with ATPgS 分子名称: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Protein tyrosine kinase 2 beta, SULFATE ION 著者 Han, S. 登録日 2009-01-26 公開日 2009-03-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284, 2009
3FZT	Crystal structure of PYK2 complexed with PF-4618433 分子名称: 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3H-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1H-pyrazol-5-yl}urea, Protein tyrosine kinase 2 beta 著者 Han, S. 登録日 2009-01-26 公開日 2009-03-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284, 2009
3G45	Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 分子名称: 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline, MAGNESIUM ION, ZINC ION, ... 著者 Staker, B.L. 登録日 2009-02-03 公開日 2010-01-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010
3FUM	Leukotriene A4 hydrolase in complex with (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 分子名称: (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol, ACETATE ION, IMIDAZOLE, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3G6U	GR DNA-binding domain:FKBP5 16bp complex-49 分子名称: DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*CP*CP*CP*TP*GP*TP*TP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*GP*GP*GP*TP*GP*TP*TP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Pufall, M.A, Yamamoto, K.R, Meijsing, S.H. 登録日 2009-02-08 公開日 2009-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 DNA binding site sequence directs glucocorticoid receptor structure and activity. Science, 324, 2009
3G8U	DNA binding domain:GilZ 16bp complex-5 分子名称: DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*TP*TP*GP*GP*GP*TP*TP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*CP*CP*CP*AP*AP*TP*GP*TP*TP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Pufall, M.A, Yamamoto, K.R, Meijsing, S.H. 登録日 2009-02-12 公開日 2009-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 DNA binding site sequence directs glucocorticoid receptor structure and activity. Science, 324, 2009
3G93	Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole 分子名称: 1-(biphenyl-4-ylmethyl)-1H-imidazole, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE 著者 Gay, S.C, Sun, L, Maekawa, K, Halpert, J.R, Stout, C.D. 登録日 2009-02-12 公開日 2009-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. Biochemistry, 48, 2009
3GAX	Crystal structure of monomeric human cystatin C stabilized against aggregation 分子名称: Cystatin-C 著者 Kolodziejczyk, R, Michalska, K, Hernandez-Santoyo, A, Wahlbom, M, Grubb, A, Jaskolski, M. 登録日 2009-02-18 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human cystatin C stabilized against amyloid formation. Febs J., 277, 2010
3G5E	Human aldose reductase complexed with IDD 740 inhibitor 分子名称: 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid, Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Podjarny, A.D, Van Zandt, M.C. 登録日 2009-02-05 公開日 2009-03-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Bioorg.Med.Chem.Lett., 19, 2009
3FQW	Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes 分子名称: Beta-2-microglobulin, CADMIUM ION, COBALT (II) ION, ... 著者 Petersen, J, Rossjohn, J. 登録日 2009-01-07 公開日 2009-03-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.927 Å) 主引用文献 Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes Proc.Natl.Acad.Sci.Usa, 106, 2009
3FRG	Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor 分子名称: 4-[(3-methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide, ARSENIC, GLYCEROL, ... 著者 Somers, D.O, Neu, M. 登録日 2009-01-08 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration. Bioorg.Med.Chem.Lett., 19, 2009
3FUG	Crystal Structure of the Retinoid X Receptor Ligand Binding Domain Bound to the Synthetic Agonist 3-[4-Hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-phenyl]acrylic Acid 分子名称: (2E)-3-[4-hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]prop-2-enoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Bourguet, W. 登録日 2009-01-14 公開日 2009-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. J.Med.Chem., 52, 2009
3G5M	Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory activity 分子名称: 6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one, FLAVIN-ADENINE DINUCLEOTIDE, Ribosyldihydronicotinamide dehydrogenase [quinone], ... 著者 Maiti, A, Sturdy, M, Marler, L, Pegan, S.D, Mesecar, A.D, Pezzuto, J.M, Cushman, M. 登録日 2009-02-05 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J.Med.Chem., 52, 2009
3G6Q	GR DNA binding domain:FKBP5 binding site complex-9 分子名称: DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*CP*CP*CP*TP*GP*TP*TP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*AP*AP*CP*AP*GP*GP*GP*TP*GP*TP*TP*CP*T)-3'), Glucocorticoid receptor, ... 著者 Pufall, M.A, Yamamoto, K.R, Meijsing, S.H. 登録日 2009-02-08 公開日 2009-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 DNA binding site sequence directs glucocorticoid receptor structure and activity. Science, 324, 2009
3FUE	Leukotriene A4 hydrolase in complex with fragment 5-chloroindole and bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-chloro-1H-indole, IMIDAZOLE, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUP	Crystal structures of JAK1 and JAK2 inhibitor complexes 分子名称: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase JAK2 著者 Williams, N.K, Bamert, R.S, Patel, O, Fantino, E, Rossjohn, J, Lucet, I.S. 登録日 2009-01-14 公開日 2009-02-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387, 2009
3FW3	Crystal Structure of soluble domain of CA4 in complex with Dorzolamide 分子名称: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 4, SULFATE ION, ... 著者 Greasley, S.E, Ferre, R.A.A, Paz, R, Wickersham, J. 登録日 2009-01-16 公開日 2009-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorg.Med.Chem., 18, 2010
3FZO	Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase 分子名称: Protein tyrosine kinase 2 beta 著者 Han, S. 登録日 2009-01-26 公開日 2009-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284, 2009
3FZR	Crystal structure of PYK2 complexed with PF-431396 分子名称: N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide, PHOSPHATE ION, Protein tyrosine kinase 2 beta 著者 Han, S. 登録日 2009-01-26 公開日 2009-03-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284, 2009
3FTW	Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate 分子名称: ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ... 著者 Davies, D.R. 登録日 2009-01-13 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUD	Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine 分子名称: ACETATE ION, IMIDAZOLE, Leukotriene A-4 hydrolase, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUR	Crystal Structure of PPARg in complex with INT131 分子名称: 2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide, CHLORIDE ION, Nuclear receptor coactivator 1, ... 著者 Wang, Z, Liu, J, Walker, N. 登録日 2009-01-14 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 INT131: a selective modulator of PPAR gamma. J.Mol.Biol., 386, 2009
3G43	Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer 分子名称: CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C 著者 Fallon, J.L, Quiocho, F.A. 登録日 2009-02-03 公開日 2009-03-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+{middle dot}calmodulins. Proc.Natl.Acad.Sci.USA, 106, 2009
3FXZ	Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172 分子名称: OCTAHEDRAL RU-PYRIDOCARBAZOLE, Serine/threonine-protein kinase PAK 1 著者 Maksimoska, J, Marmorstein, R, Meggers, E. 登録日 2009-01-21 公開日 2009-02-17 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes J.Am.Chem.Soc., 130, 2008

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