3G45

Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988

Summary for 3G45

Entry DOI	10.2210/pdb3g45/pdb
Related	3G4G 3G4I 3G4K 3G4L 3G58 3GPZ
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	97747.55
Authors	Staker, B.L. (deposition date: 2009-02-03, release date: 2010-01-19, Last modification date: 2024-02-21)
Primary citation	Burgin, A.B.,Magnusson, O.T.,Singh, J.,Witte, P.,Staker, B.L.,Bjornsson, J.M.,Thorsteinsdottir, M.,Hrafnsdottir, S.,Hagen, T.,Kiselyov, A.S.,Stewart, L.J.,Gurney, M.E. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28:63-70, 2010 Cited by PubMed: 20037581 DOI: 10.1038/nbt.1598 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation