3G45

Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	polymer	421	48442.7	2	UniProt (Q07343) Pfam (PF18100) Pfam (PF00233)	Homo sapiens (human)	DPDE4, PDE32
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, H (A, B)	8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline	non-polymer		341.4	2	Chemie (988)
5	I, J (A, B)	water	water		18.0	100	Chemie (HOH)

Sequence modifications

A, B: 241 - 294 (UniProt: Q07343)

PDB	External Database	Details
Met 240	-	expression tag
His 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag
His 663	-	expression tag
His 664	-	expression tag
His 665	-	expression tag

A, B: 305 - 659 (UniProt: Q07343)

PDB	External Database	Details
Lys 295	-	linker
Val 296	-	linker
Thr 297	-	linker
Ala 298	-	linker
Glu 299	-	linker
Glu 300	-	linker
Ala 301	-	linker
Pro 302	-	linker
Gln 303	-	linker
Pro 304	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96885.4
Non-Polymers*	Number of molecules	6
	Total formula weight	862.2
All*	Total formula weight	97747.6

*Water molecules are not included.