3FXZ

Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172

Summary for 3FXZ

Entry DOI	10.2210/pdb3fxz/pdb
Related	3FY0
Descriptor	Serine/threonine-protein kinase PAK 1, OCTAHEDRAL RU-PYRIDOCARBAZOLE (3 entities in total)
Functional Keywords	transferase, kinase, atp-binding, phosphorylation, allosteric enzyme, alternative splicing, apoptosis, cell junction, cytoplasm, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q13153
Total number of polymer chains	1
Total formula weight	34035.26
Authors	Maksimoska, J.,Marmorstein, R.,Meggers, E. (deposition date: 2009-01-21, release date: 2009-02-17, Last modification date: 2021-10-20)
Primary citation	Maksimoska, J.,Feng, L.,Harms, K.,Yi, C.,Kissil, J.,Marmorstein, R.,Meggers, E. Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes J.Am.Chem.Soc., 130:15764-15765, 2008 Cited by PubMed: 18973295 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation