3FZO
Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase
Summary for 3FZO
Entry DOI | 10.2210/pdb3fzo/pdb |
Related | 3FZP 3FZR 3FZS 3FZT |
Descriptor | Protein tyrosine kinase 2 beta (2 entities in total) |
Functional Keywords | tyrosine kinase, dfg-out, alternative splicing, atp-binding, cell membrane, cytoplasm, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q14289 |
Total number of polymer chains | 1 |
Total formula weight | 32190.32 |
Authors | |
Primary citation | Han, S.,Mistry, A.,Chang, J.S.,Cunningham, D.,Griffor, M.,Bonnette, P.C.,Wang, H.,Chrunyk, B.A.,Aspnes, G.E.,Walker, D.P.,Brosius, A.D.,Buckbinder, L. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284:13193-13201, 2009 Cited by PubMed: 19244237DOI: 10.1074/jbc.M809038200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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